ChemicalBook > CAS DataBase List > 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

Product Name
6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
CAS No.
784150-41-0
Chemical Name
6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
Synonyms
6-BroMo-4-chloro-7H-pyrro...;6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;6-Bromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 6-bromo-4-chloro-;6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB7344859
Molecular Formula
C6H3BrClN3
Formula Weight
232.47
MOL File
784150-41-0.mol
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6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Property

Density 
1.996±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
9.52±0.50(Predicted)
form 
solid
color 
Light yellow
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-B1566
Product name
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging
100mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-B1566
Product name
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging
250mg
Price
$116
Updated
2021/12/16
Matrix Scientific
Product number
059868
Product name
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Purity
95+%
Packaging
250mg
Price
$120
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-D-29
Product name
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging
250mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153031
Product name
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging
100mg
Price
$190
Updated
2021/12/16
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6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

784150-40-9

784150-41-0

Synthesis of compound 20.2. Potassium tert-butanolate (1.2 g, 10 mmol) was added to a solution of tetrahydrofuran (THF, 24 mL) of compound 20.1 (6-bromo-4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-D]pyrimidine, 800 mg, 2.2 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated sodium bicarbonate (NaHCO3) solution. The reaction mixture was extracted with ethyl acetate (EtOAc, 3 × 100 mL). The organic layers were combined, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate (Na2SO4). The solvent was evaporated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography using silica gel (SiO2) as stationary phase and hexane/ethyl acetate (100/0 to 0/100) as eluent to afford compound 20.2 (6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine, 400 mg, 80% yield). The product was characterized by 1H-NMR (200 MHz, DMSO-d6) and mass spectrometry (MS): 1H-NMR δ 13.41 (broad single peak, 1H), 8.57 (single peak, 1H), 6.79 (single peak, 1H); MS m/z 232 [M + 1]+.

References

[1] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 27
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7431 - 7448
[3] Tetrahedron Letters, 2010, vol. 51, # 27, p. 3597 - 3598

6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Suppliers

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View Lastest Price from 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 784150-41-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-06
Shanghai Rlavie Technology Co ltd
Product
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 784150-41-0
Price
US $0.00/KG
Min. Order
0.0001KG
Purity
98%min
Supply Ability
500kgs/month
Release date
2022-05-11
Dideu Industries Group Limited
Product
6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 784150-41-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-01

784150-41-0, 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINERelated Search:

6-bromo-4-chloro-1H-imidazo[4,5-c]pyridine 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

  • 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
  • 6-BroMo-4-chloro-7H-pyrro...
  • 7H-Pyrrolo[2,3-d]pyrimidine, 6-bromo-4-chloro-
  • 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
  • 6-Bromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine
  • 784150-41-0
  • CHIRAL CHEMICALS