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AZ82

Product Name
AZ82
CAS No.
1449578-65-7
Chemical Name
AZ82
Synonyms
AZ82;AZ82,AZ-82;KIFC1 inhibitor AZ82;KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem;3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-;5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide
CBNumber
CB73595708
Molecular Formula
C28H31F3N4O3S
Formula Weight
560.63
MOL File
1449578-65-7.mol
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AZ82 Property

Boiling point:
707.9±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form 
Yellow film
pka
13.25±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.33916
Product name
KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem
Packaging
5mg
Price
$197
Updated
2025/07/31
Cayman Chemical
Product number
21898
Product name
AZ82
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
21898
Product name
AZ82
Purity
≥98%
Packaging
5mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
21898
Product name
AZ82
Purity
≥98%
Packaging
10mg
Price
$311
Updated
2024/03/01
Cayman Chemical
Product number
21898
Product name
AZ82
Purity
≥98%
Packaging
25mg
Price
$593
Updated
2024/03/01
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AZ82 Chemical Properties,Usage,Production

Uses

AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.

Biological Activity

Cell permeable: yes', 'Primary Target
MT/KIFC1', 'Reversible: yes

IC 50

HSET/KIFC1: 300 nM (IC50); HSET/KIFC1: 43 nM (Ki)

References

[1] Godinho SA, et al. Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). DOI:10.1098/rstb.2013.0467
[2] Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8. DOI:10.1021/cb400186w

AZ82 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ82 Suppliers

China 28 United States 7 Global 35
Shanghai EFE Biological Technology Co., Ltd.
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15911056312
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hongquchem@qq.com
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TargetMol Chemicals Inc.
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1449578-65-7, AZ82Related Search:


  • 5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide
  • AZ82
  • KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem
  • KIFC1 inhibitor AZ82
  • 3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-
  • AZ82,AZ-82
  • 1449578-65-7
  • C28H31F3N4O3S