ChemicalBook > CAS DataBase List > AZ82
AZ82
- Product Name
- AZ82
- CAS No.
- 1449578-65-7
- Chemical Name
- AZ82
- Synonyms
- AZ82;AZ82,AZ-82;KIFC1 inhibitor AZ82;KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem;3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-;5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide
- CBNumber
- CB73595708
- Molecular Formula
- C28H31F3N4O3S
- Formula Weight
- 560.63
- MOL File
- 1449578-65-7.mol
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AZ82 Property
- Boiling point:
- 707.9±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
- form
- Yellow film
- pka
- 13.25±0.46(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 5.33916
- Product name
- KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem
- Packaging
- 5mg
- Price
- $197
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 21898
- Product name
- AZ82
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21898
- Product name
- AZ82
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21898
- Product name
- AZ82
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $311
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21898
- Product name
- AZ82
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $593
- Updated
- 2024/03/01
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AZ82 Chemical Properties,Usage,Production
Uses
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
Biological Activity
Cell permeable: yes', 'Primary Target
MT/KIFC1', 'Reversible: yes
IC 50
HSET/KIFC1: 300 nM (IC50); HSET/KIFC1: 43 nM (Ki)
References
[1] Godinho SA, et al. Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). DOI:10.1098/rstb.2013.0467
[2] Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8. DOI:10.1021/cb400186w
AZ82 Preparation Products And Raw materials
Raw materials
Preparation Products
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