CDDO-TFEA
- Product Name
- CDDO-TFEA
- CAS No.
- 932730-52-4
- Chemical Name
- CDDO-TFEA
- Synonyms
- CDDO-TFE;CDDO-TFEA;CDDO-TFEA Exclusive;2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide;Oleana-1,9(11)-dien-28-amide, 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-;(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxamide
- CBNumber
- CB73901916
- Molecular Formula
- C33H43F3N2O3
- Formula Weight
- 572.7
- MOL File
- 932730-52-4.mol
CDDO-TFEA Property
- Boiling point:
- 661.5±55.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 13.70±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 90001845
- Product name
- CDDO-TFEA
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 90001845
- Product name
- CDDO-TFEA
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 90001845
- Product name
- CDDO-TFEA
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- C4354
- Product name
- CDDO-TFEA
- Packaging
- 5mg
- Price
- $307
- Updated
- 2021/12/16
CDDO-TFEA Chemical Properties,Usage,Production
Description
The synthetic oleanane triterpenoid CDDO is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-
Uses
CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.
References
[1]. pareek tk, belkadi a, kesavapany s, et al. triterpenoid modulation of il-17 and nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. sci rep. 2011;1:201.
[2]. neymotin a, calingasan ny, wille e, et al. neuroprotective effect of nrf2/are activators, cddo ethylamide and cddo trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. free radic biol med. 2011 jul 1;51(1):88-96.
[3]. stack c, ho d, wille e, et al. triterpenoids cddo-ethyl amide and cddo-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of huntington's disease. free radic biol med. 2010 jul 15;49(2):147-58.
CDDO-TFEA Preparation Products And Raw materials
Raw materials
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