ISOGUVACINE HYDROCHLORIDE

Product Name: ISOGUVACINE HYDROCHLORIDE
CAS No.: 64603-90-3
Chemical Name: ISOGUVACINE HYDROCHLORIDE
Synonyms: C13694;isoguvacine;ISOGUVACINE HCL;Isoguvacine hydrochl;ISOGUVACINE HYDROCHLORIDE;1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid;ISOGUVACINE HYDROCHLORIDE ISO 9001：2015 REACH;4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-;1,2,3,6-Tetrahydropyridine-4-carboxylic Acid (Isoguvacine);1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE
CBNumber: CB7406481
Molecular Formula: C6H9NO2
Formula Weight: 127.14
MOL File: 64603-90-3.mol

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ISOGUVACINE HYDROCHLORIDE Property

Melting point:: 220 °C
Boiling point:: 280.8±35.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
RTECS: US5908286
storage temp.: Store at RT
solubility: H₂O: refrigerate if not used immediately.soluble
form: solid
pka: pK1:9.07 (25°C)
color: white
Water Solubility: Soluble in water

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J63243
Product name: Isoguvacine hydrochloride, 99%
Packaging: 100mg
Price: $350
Updated: 2021/12/16

Tocris

Product number: 0235
Product name: Isoguvacine hydrochloride
Purity: ≥99%(HPLC)
Packaging: 100
Price: $223
Updated: 2021/12/16

Usbiological

Product number: 255530
Product name: Isoguvacine hydrochloride
Packaging: 100mg
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008224
Product name: ISOGUVACINE
Purity: 95.00%
Packaging: 500MG
Price: $718.41
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008224
Product name: ISOGUVACINE
Purity: 95.00%
Packaging: 1G
Price: $1021.65
Updated: 2021/12/16

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ISOGUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

This base is isolated, together with Guvacine (q.v.) from the nuts of Areca catechu. It is optically inactive and yields crystalline salts: the hydrochloride, m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C. The alkaloid is faintly acid to litmus and on methylation gives the N-methyl derivative which, on more vigorous methylation yields the dimethyl compound giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust, it yields products with the characteristic pyrrole reaction.

Chemical Properties

bp 195-197°C

Uses

A GABAA receptor agonist. Anticonvulsant; antiepileptic.

Definition

ChEBI: Isoguvacine is a tetrahydropyridine.

Biological Activity

Specific GABA A receptor agonist.

References

Jahns., Ber., 21,3404 (1888) Jahns., ibid, 23, 2972 (1890) Jahns., ibid, 24,2615 (1891) Jahns., Arch. Pharrn., 229, 669 (1891) Trier., Zeit. Physiol. Chern., 85,372 (1913)

ISOGUVACINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOGUVACINE HYDROCHLORIDE Suppliers

China 29 Germany 2 India 3 Switzerland 1 United Kingdom 2 United States 10 Global 47

EMMX Biotechnology LLC

Tel: 888-539-0666
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United States Biological

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United States Biological

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CarboMer, Inc.

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Matrix Scientific

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APAC Pharmaceutical, LLC

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Riedel-de Haen AG

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MP Biomedicals, Inc.

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BIOMOL INTERNATIONAL, LP

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Natland International Corporation

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64603-90-3, ISOGUVACINE HYDROCHLORIDERelated Search:

1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE BOC-1,2,5,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID 5-HYDROXY-6-OXO-1,2,3,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRI DINECARBOXYLATE, TECH., 85 ISOGUVACINE HYDROCHLORIDE FMOC-1,2,5,6-TETRAHYDROPYRIDINE-4-CARBOXYLIC ACID AKOS 247 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylic acid Ethyl 1-benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate

isoguvacine

C13694

1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid

4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-

ISOGUVACINE HCL

ISOGUVACINE HYDROCHLORIDE

1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBOXYLIC ACIDHYDROCHLORIDE

1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE

ISOGUVACINE HYDROCHLORIDE ISO 9001：2015 REACH

Isoguvacine hydrochl

1,2,3,6-Tetrahydropyridine-4-carboxylic Acid (Isoguvacine)

64603-90-3

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Ion Channels

Ligand-Gated Ion Channels

GABA and Glycine Receptor Modulators

GABA/Glycine receptor