N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide

Product Name: N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide
CAS No.: 355406-76-7
Chemical Name: N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide
Synonyms: RIPGBM;RIP BM;RIPGBM, 10 mM in DMSO;Apoptosis,inhibit,RIPGBM,Inhibitor;N-(3-(Benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide;N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide;Acetamide, N-[1,4-dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]-
CBNumber: CB74200825
Molecular Formula: C26H21FN2O3
Formula Weight: 428.45
MOL File: 355406-76-7.mol

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N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide Property

storage temp.: Store at -20°C
solubility: DMSO : 33.33 mg/mL (77.79 mM; Need ultrasonic)
form: A crystalline solid
color: Pink to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2682
Product name: RIPGBM
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $73.53
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2682
Product name: RIPGBM
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $310
Updated: 2025/07/31

Cayman Chemical

Product number: 27860
Product name: RIPGBM
Packaging: 1mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 27860
Product name: RIPGBM
Packaging: 10mg
Price: $755
Updated: 2024/03/01

Cayman Chemical

Product number: 27860
Product name: RIPGBM
Packaging: 5mg
Price: $399
Updated: 2024/03/01

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N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide Chemical Properties,Usage,Production

Uses

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].

Biological Activity

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1]. RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex[1].

storage

Store at -20°C

References

[1]. Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.

N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide Suppliers

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355406-76-7, N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamideRelated Search:

N-[3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide

RIPGBM

Acetamide, N-[1,4-dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]-

Apoptosis,inhibit,RIPGBM,Inhibitor

N-(3-(Benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide

RIP BM

RIPGBM, 10 mM in DMSO

355406-76-7