ChemicalBook > CAS DataBase List > BMS-8

BMS-8

Product Name
BMS-8
CAS No.
1675201-90-7
Chemical Name
BMS-8
Synonyms
BMS-8;BMS-8, 10 mM in DMSO;PPI,BMS 8,BMS8,inhibit,BMS-8,Inhibitor,PD-L1,PD-1;1-(3-bromo-4-((2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid , BMS-8;2-Piperidinecarboxylic acid, 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-
CBNumber
CB74666331
Molecular Formula
C27H28BrNO3
Formula Weight
494.42
MOL File
1675201-90-7.mol
More
Less

BMS-8 Property

Boiling point:
616.9±55.0 °C(Predicted)
Density 
1.334±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Methanol: slightly soluble
form 
A crystalline solid
pka
2.35±0.20(Predicted)
color 
White to off-white
InChIKey
QRXBPPWUGITQLE-UHFFFAOYSA-N
SMILES
N1(CC2=CC=C(OCC3C=CC=C(C4=CC=CC=C4)C=3C)C(Br)=C2)CCCCC1C(O)=O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22355
Product name
BMS-8
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
22355
Product name
BMS-8
Purity
≥98%
Packaging
25mg
Price
$542
Updated
2024/03/01
Cayman Chemical
Product number
22355
Product name
BMS-8
Purity
≥98%
Packaging
500μg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
22355
Product name
BMS-8
Purity
≥98%
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
22355
Product name
BMS-8
Purity
≥98%
Packaging
10mg
Price
$230
Updated
2024/03/01
More
Less

BMS-8 Chemical Properties,Usage,Production

Description

BMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.

Uses

BMS-8 is inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.

References

[1] KATARZYNA GUZIK. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1[J]. Journal of Medicinal Chemistry, 2017, 60 13: 5857-5867. DOI: 10.1021/acs.jmedchem.7b00293

BMS-8 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BMS-8 Suppliers

China 26 United States 4 Global 30
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
939
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71615
Advantage
60
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
sales@linyuepharm.com
Country
China
ProdList
5534
Advantage
55
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23972
Advantage
60
Shandong utilizing biological technology co., LTD
Tel
15966937598
Fax
3407640895 3071519937
Email
3407650895@qq.com
Country
China
ProdList
4112
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58

1675201-90-7, BMS-8Related Search:


  • BMS-8
  • 2-Piperidinecarboxylic acid, 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-
  • 1-(3-bromo-4-((2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
  • PPI,BMS 8,BMS8,inhibit,BMS-8,Inhibitor,PD-L1,PD-1
  • 1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
  • BMS-8, 10 mM in DMSO
  • 1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid , BMS-8
  • 1675201-90-7