PF-06446846

Product Name: PF-06446846
CAS No.: 1632250-49-7
Chemical Name: PF-06446846
Synonyms: PF-6446846;PF-06446846;PF-06446846, 10 mM in DMSO;Benzamide, N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide;Threonine proteases,PF06446846,Inhibitor,80S ribosome,Selective,PF 06446846,Ser/Thr Protease,Serine proteases,Rat bone marrow,Huh7,inhibit,Serine endopeptidases,PF-06446846
CBNumber: CB74668360
Molecular Formula: C22H20ClN7O
Formula Weight: 433.89
MOL File: 1632250-49-7.mol

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PF-06446846 Property

Boiling point:: 655.5±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 87 mg/mL (200.51 mM);Ethanol: 87 mg/mL (200.51 mM)
pka: 8.69±0.10(Predicted)
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

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PF-06446846 Chemical Properties,Usage,Production

Definition

ChEBI: PF-06446846 is a triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. It has a role as an antilipemic drug and an EC 3.4.21.61 (kexin) inhibitor. It is a monochloropyridine, a member of piperidines, a tertiary carboxamide, a member of benzamides and a triazolopyridine.

PF-06446846 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06446846 Suppliers

China 13 United States 3 Global 16

Shanghai Chaolan Chemical Technology Center

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1632250-49-7, PF-06446846Related Search:

PF-06446846

PF-6446846

Threonine proteases,PF06446846,Inhibitor,80S ribosome,Selective,PF 06446846,Ser/Thr Protease,Serine proteases,Rat bone marrow,Huh7,inhibit,Serine endopeptidases,PF-06446846

(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide

Benzamide, N-(3-chloro-2-pyridinyl)-N-(3R)-3-piperidinyl-4-(3H-1,2,3-triazolo[4,5-b]pyridin-3-yl)-

PF-06446846, 10 mM in DMSO

1632250-49-7