ChemicalBook > CAS DataBase List > 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Product Name
2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
CAS No.
68682-01-9
Chemical Name
2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Synonyms
6PNG;(2R/S)-6-PNG;(2R/S)6PNG,(2R/S) 6 PNG;(2R/S)-6-PNG, 10 mM in DMSO;Naringenin 6-Prenyl Racemate;5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one;2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-
CBNumber
CB74902675
Molecular Formula
C20H20O5
Formula Weight
340.37
MOL File
68682-01-9.mol
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2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Property

Melting point:
212-214 °C(Solv: methanol (67-56-1))
Boiling point:
604.2±55.0 °C(Predicted)
Density 
1.314±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
pka
8.06±0.40(Predicted)
color 
White to off-white
Stability:
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
75602
Product name
6-Prenylnaringenin
Purity
analytical standard
Packaging
5MG
Price
$729
Updated
2022/05/15
Tocris
Product number
6651
Product name
(2R/S)-6-PNG
Purity
≥98%(HPLC)
Packaging
5
Price
$185
Updated
2021/12/16
TRC
Product number
P712905
Product name
6-Prenyl-rac-naringenin
Packaging
50mg
Price
$1540
Updated
2021/12/16
ChemScene
Product number
CS-0120480
Product name
(2R/S)-6-PNG
Purity
≥99.0%
Packaging
5mg
Price
$520
Updated
2021/12/16
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2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Chemical Properties,Usage,Production

Uses

6-Prenyl-rac-naringenin is a natural product isolated from Cudrania tricuspidata root which showed growth inhibition against Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae.

Definition

ChEBI: (S)-4',5,7-Trihydroxy-6-prenylflavanone is a member of flavanones.

in vivo

(2R/S)-6-PNG (6-Prenylnaringenin; 10-30 mg/kg; i.p.; single dose; 15 min before Na2S) significantly reduced the Na2S-induced nociceptive behavior and/or referred hyperalgesia in onscious mice with intracolonic (i.col.) administration of Na2S, an H2S donor[1].
(2R/S)-6-PNG (30 mg/kg; i.p.) prevents the increased number of phosphorylated ERK-positive cells following i.col. Na2S in laminae I-II, V-VI and X to which the primary afferent neurons project, and the Na2S-induced increase in the phosphorylated ERK-positive cell number[1].
(2R/S)-6-PNG (0.01-1 and 0.1-10 nmol/paw; intraplantar administration) restores the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and by i.p. administration of Oxaliplatin (OHP) a, respectively, in a dose-dependent manner[1].
(2R/S)-6-PNG (20-30 mg/kg; i.p.) significantly reverses the PSNL-induced allodynia. (2R/S)-6-PNG (10-20 mg/kg; i.p.) significantly reverses the OHP-induced allodynia (5 mg/kg; i.p.; single dose)[1].

IC 50

T-type calcium channel

2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Suppliers

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68682-01-9, 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-oneRelated Search:


  • 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
  • 6PNG
  • (2R/S)-6-PNG
  • Naringenin 6-Prenyl Racemate
  • (2R/S)6PNG,(2R/S) 6 PNG
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-
  • (2R/S)-6-PNG, 10 mM in DMSO
  • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one
  • 68682-01-9