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Thalidomide-4-O-C6-NH2 hydrochloride

Product Name
Thalidomide-4-O-C6-NH2 hydrochloride
CAS No.
2245697-88-3
Chemical Name
Thalidomide-4-O-C6-NH2 hydrochloride
Synonyms
-ether-alkylC6-amine;3-dione hydrochloride;4-((6-aminohexyl)oxy)-2-(2;Thalidomide-O-C6-NH2 hydrochloride;Thalidomide 4'-ether-alkylC6-amine;Thalidomide-4-O-C6-NH2 (hydrochloride);4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Hydrochloride;4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;4-[(6-aminohexyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
CBNumber
CB75442066
Molecular Formula
C19H24ClN3O5
Formula Weight
409.87
MOL File
2245697-88-3.mol
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Thalidomide-4-O-C6-NH2 hydrochloride Property

storage temp. 
2-8°C, sealed storage, away from moisture and light
solubility 
Soluble in DMSO
form 
Solid
color 
Off-white to gray
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS106307
Product name
4-(6-Aminohexyloxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl
Purity
97%
Packaging
250mg
Price
$527
Updated
2021/12/16
Acrotein
Product number
AS01449
Product name
4-(6-Aminohexyloxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl
Purity
97%
Packaging
0.1g
Price
$201.67
Updated
2021/12/16
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Thalidomide-4-O-C6-NH2 hydrochloride Chemical Properties,Usage,Production

Description

Thalidomide-O-C6-Amine HCl is a functionalized cereblon ligand used for PROTAC research. It incorporates an E3 ligase ligand and a C6 alkyl linker to conjugate to a target protein.

Uses

Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543(7644):270-274. DOI:10.1038/nature21688

Thalidomide-4-O-C6-NH2 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-4-O-C6-NH2 hydrochloride Suppliers

China 30 United States 3 Global 33
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
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View Lastest Price from Thalidomide-4-O-C6-NH2 hydrochloride manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Thalidomide-O-C6-NH2 hydrochloride 2245697-88-3
Price
US $0.00/g
Min. Order
1g
Purity
>95.00%
Supply Ability
1g
Release date
2024-04-01

2245697-88-3, Thalidomide-4-O-C6-NH2 hydrochlorideRelated Search:

Thalidomide-O-C5-acid Thalidomide-O-C3-acid Thalidomide-O-C6-acid Thalidomide-O-C10-NH2 Thalidomide-O-C6-NH2 Thalidomide-linker 9 Thalidomide-linker 6 Thalidomide-O-C6-NH2 TFA Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Propanoic acid, 3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 1H-Isoindole-1,3(2H)-dione, 4-[(7-aminoheptyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Thalidomide-4-O-C8-NH2 5,6-dichloro-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

  • 4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
  • 4-((6-Aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
  • -ether-alkylC6-amine
  • Thalidomide-O-C6-NH2 hydrochloride
  • 1H-?Isoindole-?1,?3(2H)?-?dione, 4-?[(6-?aminohexyl)?oxy]?-?2-?(2,?6-?dioxo-?3-?piperidinyl)?-?, hydrochloride
  • 4-[(6-aminohexyl)oxy]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
  • 3-dione hydrochloride
  • 4-((6-aminohexyl)oxy)-2-(2
  • Inhibitor,Thalidomide-O-C-6-NH2 hydrochloride,dTAG-13,inhibit,E3 Ligase Ligand-Linker Conjugates,FKBP12(F36V),ThalidomideOC6NH2 hydrochloride,BET,Thalidomide O C6 NH2 hydrochloride
  • Thalidomide-4-O-C6-NH2 (hydrochloride)
  • 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Hydrochloride
  • Thalidomide 4'-ether-alkylC6-amine
  • 2245697-88-3