FGTI-2734

Product Name: FGTI-2734
CAS No.: 1247018-19-4
Chemical Name: FGTI-2734
Synonyms: FGTI-2734;FGTI-2734, 10 mM in DMSO;N-(2-((4-Cyano-2-fluorophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)-N-(cyclohexylmethyl)pyridine-2-sulfonamide;2-Pyridinesulfonamide, N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)-;pancreatic,patient-derived,geranylgeranyl,farnesyl,inhibit,Farnesyl Transferase,mimetic,FGTI2734,Inhibitor,membrane,Ftase,FGTI-2734,KRAS,FGTI 2734,C-terminal,transferase,tumors,localization
CBNumber: CB75540586
Molecular Formula: C26H31FN6O2S
Formula Weight: 510.63
MOL File: 1247018-19-4.mol

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FGTI-2734 Property

Boiling point:: 770.1±70.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);97.92(Max Conc. mM)
form: Solid
pka: 6.60±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0099052
Product name: FGTI-2734
Purity: 99.48%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0099052
Product name: FGTI-2734
Purity: 99.48%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0099052
Product name: FGTI-2734
Purity: 99.48%
Packaging: 50mg
Price: $2000
Updated: 2021/12/16

ChemScene

Product number: CS-0099052
Product name: FGTI-2734
Purity: 99.48%
Packaging: 100mg
Price: $3500
Updated: 2021/12/16

DC Chemicals

Product number: DC32723
Product name: FGTI-2734
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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FGTI-2734 Chemical Properties,Usage,Production

Description

FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor. It can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.

Uses

FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors[1].

in vivo

FGTI-2734 (intraperitoneally; 100 mg/kg/daily for 18 to 25 days) only inhibits tumor growth in mutant KRAS-dependent tumors but not in mutant KRAS-independent tumors^[1].

Animal Model:	Male SCID-bg mice following injection of MiaPaCa2, L3.6pl, Calu6, A549, H460 and DLD1 cancer cells^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneally; daily; for 18 to 25 days
Result:	Inhibited tumor growth in mutant KRAS-dependent tumors.

target

FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively.

References

[1] Kazi A, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clin Cancer Res. 2019 Jun 21. DOI:10.1158/1078-0432.CCR-18-3399

FGTI-2734 Preparation Products And Raw materials

Raw materials

Preparation Products

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FGTI-2734 Suppliers

China 26 United States 3 Global 29

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1247018-19-4, FGTI-2734Related Search:

FGTI-2734

2-Pyridinesulfonamide, N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)-

pancreatic,patient-derived,geranylgeranyl,farnesyl,inhibit,Farnesyl Transferase,mimetic,FGTI2734,Inhibitor,membrane,Ftase,FGTI-2734,KRAS,FGTI 2734,C-terminal,transferase,tumors,localization

FGTI-2734, 10 mM in DMSO

N-(2-((4-Cyano-2-fluorophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)-N-(cyclohexylmethyl)pyridine-2-sulfonamide

1247018-19-4

C26H31FN6O2S