SEC inhibitor KL-1

Product Name: SEC inhibitor KL-1
CAS No.: 900308-84-1
Chemical Name: SEC inhibitor KL-1
Synonyms: KL1;KL-1;KL 1;SEC inhibitor KL-1;SEC inhibitor KL-1, 10 mM in DMSO;N-(5-Chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide;2-Butenamide, N-(5-chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxo-;(2E)-N-(5-Chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide;SEC inhibitor KL 1,KL 1,Inhibitor,SEC inhibitor KL-1,inhibit,KL1,SEC inhibitor KL1
CBNumber: CB75540748
Molecular Formula: C18H16ClNO4
Formula Weight: 345.78
MOL File: 900308-84-1.mol

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SEC inhibitor KL-1 Property

Boiling point:: 552.4±50.0 °C(Predicted)
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 41.67 mg/mL (120.51 mM)
pka: 8.09±0.50(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611271
Product name: SEC inhibitor KL-1
Purity: >98%
Packaging: 10mg
Price: $542.3
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611271
Product name: SEC inhibitor KL-1
Purity: >98%
Packaging: 25mg
Price: $765
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611271
Product name: SEC inhibitor KL-1
Purity: >98%
Packaging: 100mg
Price: $1654.1
Updated: 2021/12/16

DC Chemicals

Product number: DC11391
Product name: SECinhibitorKL-1
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC11391
Product name: SECinhibitorKL-1
Purity: >98%
Packaging: 1g
Price: $1900
Updated: 2021/12/16

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SEC inhibitor KL-1 Chemical Properties,Usage,Production

Uses

SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM[1][2].

in vivo

SEC inhibitor KL-1 (50 mg/kg, administered intraperitoneally, once daily, 15 days) disrupts SEC, which can slow down tumor progression and improve survival rates in MDA231-LM2 tumor mice^[2].

Animal Model:	Mouse MDA231-LM2 tumor model^[2]
Dosage:	50 mg/kg, once a day, 15 days
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced tumor volume and significantly extended survival time of recipient mice.

References

[1] Hiroaki Katagi, et al. Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. Neuro Oncol. 2021 Aug 2;23(8):1348-1359. DOI:10.1093/neuonc/noab009
[2] Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779. DOI:10.1016/j.cell.2018.09.027

SEC inhibitor KL-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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SEC inhibitor KL-1 Suppliers

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900308-84-1, SEC inhibitor KL-1Related Search:

KL-1

SEC inhibitor KL-1

KL1;KL-1;KL 1

SEC inhibitor KL 1,KL 1,Inhibitor,SEC inhibitor KL-1,inhibit,KL1,SEC inhibitor KL1

2-Butenamide, N-(5-chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxo-

N-(5-Chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide

SEC inhibitor KL-1, 10 mM in DMSO

(2E)-N-(5-Chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide

900308-84-1