SEC inhibitor KL-1
- Product Name
- SEC inhibitor KL-1
- CAS No.
- 900308-84-1
- Chemical Name
- SEC inhibitor KL-1
- Synonyms
- KL1;KL-1;KL 1;SEC inhibitor KL-1;SEC inhibitor KL-1, 10 mM in DMSO;N-(5-Chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide;2-Butenamide, N-(5-chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxo-;(2E)-N-(5-Chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide;SEC inhibitor KL 1,KL 1,Inhibitor,SEC inhibitor KL-1,inhibit,KL1,SEC inhibitor KL1
- CBNumber
- CB75540748
- Molecular Formula
- C18H16ClNO4
- Formula Weight
- 345.78
- MOL File
- 900308-84-1.mol
SEC inhibitor KL-1 Property
- Boiling point:
- 552.4±50.0 °C(Predicted)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 41.67 mg/mL (120.51 mM)
- pka
- 8.09±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- orb611271
- Product name
- SEC inhibitor KL-1
- Purity
- >98%
- Packaging
- 10mg
- Price
- $542.3
- Updated
- 2021/12/16
- Product number
- orb611271
- Product name
- SEC inhibitor KL-1
- Purity
- >98%
- Packaging
- 25mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- orb611271
- Product name
- SEC inhibitor KL-1
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1654.1
- Updated
- 2021/12/16
- Product number
- DC11391
- Product name
- SECinhibitorKL-1
- Purity
- >98%
- Packaging
- 250mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- DC11391
- Product name
- SECinhibitorKL-1
- Purity
- >98%
- Packaging
- 1g
- Price
- $1900
- Updated
- 2021/12/16
SEC inhibitor KL-1 Chemical Properties,Usage,Production
Uses
SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM[1][2].
in vivo
SEC inhibitor KL-1 (50 mg/kg, administered intraperitoneally, once daily, 15 days) disrupts SEC, which can slow down tumor progression and improve survival rates in MDA231-LM2 tumor mice[2].
| Animal Model: | Mouse MDA231-LM2 tumor model[2] |
| Dosage: | 50 mg/kg, once a day, 15 days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced tumor volume and significantly extended survival time of recipient mice. |
References
[1] Hiroaki Katagi, et al. Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. Neuro Oncol. 2021 Aug 2;23(8):1348-1359. DOI:10.1093/neuonc/noab009
[2] Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779. DOI:10.1016/j.cell.2018.09.027
SEC inhibitor KL-1 Preparation Products And Raw materials
Raw materials
Preparation Products
SEC inhibitor KL-1 Suppliers
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