3-Methoxysalicylaldehyde
- Product Name
- 3-Methoxysalicylaldehyde
- CAS No.
- 148-53-8
- Chemical Name
- 3-Methoxysalicylaldehyde
- Synonyms
- 2-HYDROXY-3-METHOXYBENZALDEHYDE;O-VANILLIN;O-VANILLIN (2-HYDROXY-3-METHOXYBENZALDEHYDE);Benzaldehyde, 2-hydroxy-3-methoxy-;2-VANILLIN;Ortho vanillin;NC 005;NSC 2150;o-Vanilin;o-Vanilline
- CBNumber
- CB7690237
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 148-53-8.mol
3-Methoxysalicylaldehyde Property
- Melting point:
- 40-42 °C (lit.)
- Boiling point:
- 265-266 °C (lit.)
- Density
- 1.2143 (rough estimate)
- refractive index
- 1.4945 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- pK1:7.912 (25°C)
- form
- Low Melting Solid
- color
- Pale yellow to brown
- Water Solubility
- slightly soluble
- Sensitive
- Air Sensitive
- BRN
- 471913
- Stability:
- Hygroscopic
- LogP
- 1.370
- CAS DataBase Reference
- 148-53-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzaldehyde, 2-hydroxy-3-methoxy-(148-53-8)
- EPA Substance Registry System
- Benzaldehyde, 2-hydroxy-3-methoxy- (148-53-8)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 23-36-24/25-36/37/39-27-26
- WGK Germany
- 3
- RTECS
- CU6530000
- F
- 10-23
- TSCA
- Yes
- HS Code
- 29124900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 120804
- Product name
- o-Vanillin
- Purity
- 99%
- Packaging
- 10g
- Price
- $58.1
- Updated
- 2025/07/31
- Product number
- 120804
- Product name
- o-Vanillin
- Purity
- 99%
- Packaging
- 100g
- Price
- $108
- Updated
- 2025/07/31
- Product number
- H0262
- Product name
- o-Vanillin
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- H0262
- Product name
- o-Vanillin
- Purity
- >99.0%(GC)
- Packaging
- 100g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- 120804
- Product name
- o-Vanillin
- Purity
- 99%
- Packaging
- 500g
- Price
- $122
- Updated
- 2025/07/31
3-Methoxysalicylaldehyde Chemical Properties,Usage,Production
Chemical Properties
Pale yellow to brown low melting solid
Uses
o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII). It is also used in the study of mutagenesis and as a synthetic precursor for pharmaceuticals.
Uses
o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis. It was used in the synthesis of new ligand for Fe(III) and Al(lII).
Uses
A positional isomer of Vanillin. o-Vanillin is a more potent antioxidant than Vanillin.
Definition
ChEBI: A member of the class of benzaldehydes that is salicylaldehyde substituted by a methoxy group at position 3.
Hazard
ortho-Vanillin is harmful if ingested, irritating to eyes, skin and respiratory system, but has an unmistakable high LD50 of 1330 mg/kg in mice.
Biochem/physiol Actions
o-Vanillin induces DNA damage as detected by comet assay.
Synthesis
2591-86-8
217813-03-1
32040-06-5
148-53-8
GENERAL METHOD: A mixed solution of 3-methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (53 μL, 0.20 mmol) with N-formylpiperidine (2.0 mmol) in acetonitrile (1.4 mL) was added to tetrabutylammonium fluoride (TBAF, 1.0 M acetonitrile solution, 0.60 mL, 0.60 mmol) under argon protection at room temperature. After the reaction mixture was stirred at the same temperature for 3 h, water (0.1 mL) was added. Subsequently, the reaction mixture was concentrated under reduced pressure. The residue was purified by fast silica gel column chromatography with the eluent ethyl acetate/hexane (1/20 to 1/8 containing 2% dichloromethane) to afford the target products 1-(3-methoxyphenyl)piperidine and o-vanillin.
References
[1] Tetrahedron, 2012, vol. 68, # 1, p. 179 - 189
3-Methoxysalicylaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methoxysalicylaldehyde Suppliers
- Tel
- 0830-8999890 13883082125
- 511598975@qq.com
- Country
- China
- ProdList
- 13
- Advantage
- 58
- Tel
- 0531-88062576 13791023792
- Fax
- QQ:395595425
- sales@typechem.com
- Country
- China
- ProdList
- 75
- Advantage
- 58
- Tel
- 13854830608; 13854830608
- 13854830608@163.com
- Country
- China
- ProdList
- 2630
- Advantage
- 58
- Tel
- 15317029879 15317029879
- shkcsy@yeah.net
- Country
- China
- ProdList
- 12
- Advantage
- 58
- Tel
- 021-69106960 13701823733
- Fax
- 021-69106780
- 13701823733@163.com
- Country
- China
- ProdList
- 4641
- Advantage
- 60
- Tel
- 18163336578
- 2139086656@qq.com
- Country
- China
- ProdList
- 2216
- Advantage
- 58
- Tel
- +86-29-88665278 18392371173
- sales@vedachem.com
- Country
- China
- ProdList
- 50
- Advantage
- 58
- Tel
- 0796-828-2352 18979604038
- 1182634205@qq.com
- Country
- China
- ProdList
- 302
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
View Lastest Price from 3-Methoxysalicylaldehyde manufacturers
- Product
- 3-Methoxysalicylaldehyde 148-53-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-10-28
- Product
- 3-Methoxysalicylaldehyde 148-53-8
- Price
- US $0.00/KG
- Min. Order
- 20KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-10
- Product
- 3-Methoxysalicylaldehyde 148-53-8
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-11-29