ChemicalBook > CAS DataBase List > 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Product Name
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS No.
187949-90-2
Chemical Name
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Synonyms
BUTTPARK 23\09-45;RARECHEM AL BO 0714;SALOR-INT L252034-1EA;5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC;5-amino-1-(4-fluorophenyl)-4-pyrazolecarboxylic acid;5-Amino-1-(4-fluorophenyl)pyrazole-4-carboxylic Acid;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-fluorophenyl)-;5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole, 1-(5-Amino-4-carboxy-1H-pyrazol-1-yl)-4-fluorobenzene
CBNumber
CB7737262
Molecular Formula
C10H8FN3O2
Formula Weight
221.19
MOL File
187949-90-2.mol
More
Less

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Property

storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Solid
More
Less

Safety

HS Code 
2933199090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L252034
Product name
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$30.7
Updated
2025/07/31
Sigma-Aldrich
Product number
L252034
Product name
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
Purity
AldrichCPR
Packaging
250MG
Price
$29.8
Updated
2024/03/01
TRC
Product number
A630488
Product name
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H57-3-54
Product name
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
Purity
98%
Packaging
1g
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA56469
Product name
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
Packaging
250mg
Price
$77.5
Updated
2021/12/16
More
Less

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

138907-68-3

187949-90-2

mmol) in a solvent mixture of methanol (200 mL). The reaction mixture was heated to reflux for 17 h, followed by cooling to room temperature and filtration. The filtrate was acidified with 2 N HCl solution to pH=7. The precipitated solid was collected by filtration and dried under reduced pressure to afford the target compound 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid as a light yellow solid (18.64 g, 95% yield), which was used in subsequent reactions without further purification.

References

[1] Patent: WO2008/53136, 2008, A1. Location in patent: Page/Page column 36
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5032 - 5038
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 5, p. 1562 - 1575
[4] Patent: WO2008/74814, 2008, A1. Location in patent: Page/Page column 56
[5] Patent: WO2008/777, 2008, A2. Location in patent: Page/Page column 58-59

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Suppliers

China 46 France 1 Germany 1 India 3 Russia 1 Switzerland 1 United Kingdom 6 United States 13 Global 72
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4986
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60

187949-90-2, 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDRelated Search:

5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-(4-FLUOROPHENYL)-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ethyl 5-amino-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate ethyl 5-amino-1-(3-chloro-4-fluorophenyl)-3-cyclopentyl-1H-pyrazole-4-carboxylate BUTTPARK 34\09-39 ethyl 5-amino-3-cyclopentyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate 5-(BOC-AMINO)-1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-(CBZ-AMINO)-1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-AMINO-1-(2-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 3-AMINO-6-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)PYRAZOLO[3,4-D][1,3]OXAZIN-4(1H)-ONE ethyl 5-amino-1-(3-chloro-4-fluorophenyl)-3-cyclobutyl-1H-pyrazole-4-carboxylate ETHYL 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-AMINO-1-(2,4-DIFLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

  • SALOR-INT L252034-1EA
  • RARECHEM AL BO 0714
  • 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
  • BUTTPARK 23\09-45
  • 5-amino-1-(4-fluorophenyl)-4-pyrazolecarboxylic acid
  • 5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole
  • 5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole, 1-(5-Amino-4-carboxy-1H-pyrazol-1-yl)-4-fluorobenzene
  • 5-Amino-1-(4-fluorophenyl)pyrazole-4-carboxylic Acid
  • 1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-fluorophenyl)-
  • 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC
  • 187949-90-2