2,5-Dichloropyrimidine
- Product Name
- 2,5-Dichloropyrimidine
- CAS No.
- 22536-67-0
- Chemical Name
- 2,5-Dichloropyrimidine
- Synonyms
- EOS-60492;2,5-Dichlo;2,5-chloropyrimidine;2,5-DICHLOROPYRIMIDINE;Macitentan Impurity 32;2,5‐Dichloropyridimidine;2,5-Dichloro-1,3-diazine;Pyrimidine, 2,5-dichloro-;2,5-Dichloropyrimidine>2,5-Dichloropyrimidine 97%
- CBNumber
- CB7750461
- Molecular Formula
- C4H2Cl2N2
- Formula Weight
- 148.98
- MOL File
- 22536-67-0.mol
2,5-Dichloropyrimidine Property
- Melting point:
- 48-55 °C
- Boiling point:
- 190°C
- Density
- 1.493
- Flash point:
- 140°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -2.84±0.22(Predicted)
- form
- Powder
- color
- Off-white
- Water Solubility
- Slightly soluble in water.
- λmax
- 268nm(EtOH)(lit.)
- InChI
- InChI=1S/C4H2Cl2N2/c5-3-1-7-4(6)8-2-3/h1-2H
- InChIKey
- CEJAHXLRNZJPQH-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)C=N1
- CAS DataBase Reference
- 22536-67-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 720917
- Product name
- 2,5-Dichloropyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $21.36
- Updated
- 2025/07/31
- Product number
- D4045
- Product name
- 2,5-Dichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- D4045
- Product name
- 2,5-Dichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $172
- Updated
- 2025/07/31
- Product number
- D436605
- Product name
- 2,5-Dichloropyrimidine
- Packaging
- 10g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- 032438
- Product name
- 2,5-Dichloropyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $13
- Updated
- 2021/12/16
2,5-Dichloropyrimidine Chemical Properties,Usage,Production
Uses
2,5-Dichloropyrimidine acid is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Preparation
2,5-Dichloropyrimidine was synthesised from 2-hydroxypyrimidine hydrochloride by treatment with aqueous chlorine solution. Reaction of the product with phosphoryl chloride in the presence of N,N-dimethylaniline gave the desired product in 40% yield. The sample was then purified by sublimation.
Synthesis
1003845-06-4
22536-67-0
Step 2: Synthesis of 2,5-dichloropyrimidine To a stirred mixed solution of (2-chloropyrimidin-5-yl)boronic acid (0.5 g, 3.164 mmol) and cuprous chloride (CuCl, 0.569 g, 6.329 mmol) in acetonitrile (MeCN, 20 mL), N-chlorosuccinimide (NCS, 0.084 g, 6.329 mmol) was slowly added. The reaction mixture was heated and refluxed at 80 °C for 16 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated sodium bicarbonate (NaHCO3) solution to 8. Subsequently, the reaction mixture was extracted with diethyl ether to separate the organic layer. The organic layer was washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate (Na2SO4). The organic phase was concentrated under reduced pressure to give light yellow solid 2,5-dichloropyrimidine (0.2 g, 75% yield). Mass spectrometry (MS) analysis showed a molecular ion peak m/z 148.9 [M++1].
storage
Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.
structure and hydrogen bonding
C4H2Cl2N2, M=148.98 monoclinic, space group P21/m with a=6.077(3), b=19.771(8), c=7.399(3) ?, β=101.23(6)°, U=872 ?3 [from 2θ values of 29 reflections measured at±ω, 25 ≤2θ ≤ 38°, λ = 0.710 73?, T=150.0 K], Dcalc=1.702 g cm-3, Z=6, μ =0.993 mm-1[1].
References
[1] Blake A, et al. Structure Analysis Restrained by ab Initio Calculations: The Molecular Structure of 2,5-Dichloropyrimidine in Gaseous and Crystalline Phases. The Journal of Physical Chemistry, 1996; 100: 12280–12287.
2,5-Dichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-Dichloropyrimidine Suppliers
- Tel
- 0519-0519-83812535
- sales@qinuochem.com
- Country
- China
- ProdList
- 287
- Advantage
- 60
- Tel
- 0519-87310015 13813530041
- Fax
- 0519-87310015
- 200601296@qq.com
- Country
- China
- ProdList
- 323
- Advantage
- 58
- Tel
- 0838-5675166 15883665058
- Fax
- 0838-5675535
- nbcxkj@126.com
- Country
- China
- ProdList
- 918
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0418-6530555 2855550
- Fax
- +86-418-6502885
- Country
- China
- ProdList
- 338
- Advantage
- 69
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
View Lastest Price from 2,5-Dichloropyrimidine manufacturers
- Product
- 2,5-Dichloropyrimidine 22536-67-0
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-22
- Product
- 2,5-Dichloropyrimidine 22536-67-0
- Price
- US $1250.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-26
- Product
- 2,5-Dichloropyrimidine 22536-67-0
- Price
- US $36.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08