ASISCHEM A03574
- Product Name
- ASISCHEM A03574
- CAS No.
- 110099-94-0
- Chemical Name
- ASISCHEM A03574
- Synonyms
- 2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID;ASISCHEM A03574;ASISCHEM A03574 ISO 9001：2015 REACH;2-(Methylthio)pyrimidine-5-carboxylicaci;2-(Methylthio)-5-pyrimidinecarboxylic acid;5-Pyrimidinecarboxylic acid, 2-(methylthio)-;2-(methylthio)pyrimidine-5-carboxylic acid(SALTDATA: FREE)
- CBNumber
- CB7799264
- Molecular Formula
- C6H6N2O2S
- Formula Weight
- 170.19
- MOL File
- 110099-94-0.mol
ASISCHEM A03574 Property
- Melting point:
- 264-266 °C
- Boiling point:
- 378.4±15.0 °C(Predicted)
- Density
- 1.45
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.82±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M725513
- Product name
- 2-(Methylthio)-5-pyrimidinecarboxylicAcid
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- X8931
- Product name
- 2-(Methylthio)pyrimidine-5-carboxylicacid
- Packaging
- 1g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- 073037
- Product name
- 2-(Methylthio)pyrimidine-5-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $393
- Updated
- 2021/12/16
- Product number
- CHM0097179
- Product name
- 2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1009.47
- Updated
- 2021/12/16
- Product number
- 073037
- Product name
- 2-(Methylthio)pyrimidine-5-carboxylic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1118
- Updated
- 2021/12/16
ASISCHEM A03574 Chemical Properties,Usage,Production
Uses
2-(Methylthio)-5-pyrimidinecarboxylic Acid was useful for studying antimycotic activity of methyl 2,4-disubstituted 5-pyrimidinecarboxylates, 2,?4-?disubstituted 5-?pyrimidinecarboxylic acids and 2,?4-?disubstituted pyrimidines.
Synthesis
73781-88-1
110099-94-0
General procedure for the synthesis of 2-(methylthio)pyrimidine-5-carboxylic acid from ethyl 2-(methylthio)pyrimidine-5-carboxylate: Synthesis Example 29; Synthesis of Compound 167; Ethyl 2-(methylthio)-5-pyrimidinecarboxylate (1 g, 5 mmol) was dissolved in methanol (15 mL). 1N sodium hydroxide solution (6 mL) was added and the reaction mixture was stirred for 1 hour. Methanol was removed by rotary evaporator and concentrated. Hydrochloric acid (500 μL) was added and the resulting precipitate was filtered, washed with water and dried under vacuum to give 811 mg (95% yield) of the target product. The resulting pyrimidine carboxylic acid was coupled with 4-fluoroaniline using EEDQ (as described in Synthesis Example 1) to give 911 mg (73% yield) of pyrimidine formamide intermediate. The thiomethyl ether portion of pyrimidine formamide (800 mg, 3.1 mmol) was oxidized with m-chloroperoxybenzoic acid (530 mg, 3.1 mmol) in acetonitrile (150 mL) for 1 hr at room temperature, and the resulting precipitate was filtered and dried under vacuum to give 300 mg (35% yield) of the oxidized product. The crude product (300 mg) was dissolved in anhydrous N,N-dimethylformamide (20 mL) and sodium sulfide (124 mg, 2 mmol) was added. The reaction mixture was gently refluxed for 2 h. Ethyl acetate (100 mL) was subsequently added and the organic layer was washed with water. The organic solvent was removed by rotary evaporator and the 6-mercapto-pyrimidinecarboxamide intermediate was purified by preparative HPLC to give 18 mg of product. Finally, alkylation of 6-mercapto-pyrimidinecarboxamide with 2-bromomethyl-phenylboronic acid using Method B afforded 10 mg (36% yield) of compound 163 as a white solid.ESI-MS m/z = 384.0 [M + H]+.
References
[1] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986, vol. 40, # 9, p. 764 - 767
[2] Patent: US2010/210593, 2010, A1. Location in patent: Page/Page column 50
[3] Patent: EP2942346, 2015, A1. Location in patent: Paragraph 0191
[4] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0389
[5] Journal of Chemical Research, 2007, # 8, p. 490 - 493
ASISCHEM A03574 Preparation Products And Raw materials
Raw materials
Preparation Products
ASISCHEM A03574 Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- 13524892556
- Fax
- (86) 21 51969655， QQ： 263541193
- sales-cn@potentpharm.com
- Country
- China
- ProdList
- 1011
- Advantage
- 55
- Tel
- 18151128828
- Fax
- -
- hc-sales@foxmail.com
- Country
- China
- ProdList
- 2647
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7992
- Advantage
- 55
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
View Lastest Price from ASISCHEM A03574 manufacturers
- Product
- ASISCHEM A03574 110099-94-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-15