2-FLUOROISONICOTINONITRILE

Product Name: 2-FLUOROISONICOTINONITRILE
CAS No.: 3939-14-8
Chemical Name: 2-FLUOROISONICOTINONITRILE
Synonyms: 4-Cyano-2-fluoroyridine;4-CYANO-2-FLUOROPYRIDINE;2-FLUOROISONICOTINONITRILE;2-Fluoroisonicotinonitrile98%;2-Fluoroisonicotinonitrile 98%;2-fluoro-4-Pyridinecarbonitrile;2-fluoropyridine-4-carbonitrile;4-Pyridinecarbonitrile, 2-fluoro-;4-Cyano-2-fluoropyridine, 97%, 97%;2-FLUOROISONICOTINONITRILE ISO 9001：2015 REACH
CBNumber: CB7837296
Molecular Formula: C6H3FN2
Formula Weight: 122.1
MOL File: 3939-14-8.mol

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2-FLUOROISONICOTINONITRILE Property

Melting point:: 29-34 °C
Boiling point:: 204.9±20.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
Flash point:: 82 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to lump
pka: -3.79±0.10(Predicted)
color: White to Almost white
Water Solubility: Insoluble in water.

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-37/38-41
Safety Statements: 26-36/37
RIDADR: UN3439
WGK Germany: 1
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 704016
Product name: 4-Cyano-2-fluoropyridine
Purity: 97%
Packaging: 5g
Price: $64.03
Updated: 2025/07/31

Sigma-Aldrich

Product number: 704016
Product name: 4-Cyano-2-fluoropyridine
Purity: 97%
Packaging: 1g
Price: $22.1
Updated: 2023/06/20

TCI Chemical

Product number: C3383
Product name: 4-Cyano-2-fluoropyridine
Purity: >99.0%(GC)
Packaging: 5g
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: C3383
Product name: 4-Cyano-2-fluoropyridine
Purity: >99.0%(GC)
Packaging: 25g
Price: $193
Updated: 2025/07/31

Usbiological

Product number: 276648
Product name: 2-Fluoropyridine-4-carbonitrile
Packaging: 5g
Price: $359
Updated: 2021/12/16

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2-FLUOROISONICOTINONITRILE Chemical Properties,Usage,Production

Uses

4-Cyano-2-fluoropyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis

33252-30-1

3939-14-8

General procedure for the synthesis of 4-cyano-2-fluoropyridine from 2-chloro-4-cyanopyridine: 2-chloro-4-cyanopyridine (6.0 g, 43.5 mmol), potassium fluoride (7.56 g, 130.3 mmol), and tetrabutylphosphonium bromide (14.8 g, 43.7 mmol) were dissolved in 1-methyl-2-pyrrolidinone (20 mL) and heated to 100° C. The reaction was carried out at 100° C for 18 h. The reaction was carried out in the following manner. C for 18 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the target product 4-cyano-2-fluoropyridine (2.3 g, 43% yield). The mass spectrum (ES) showed m/z 123.1 ([M + H]+). NMR hydrogen spectrum (400 MHz, CDCl3) δ 8.43 (d, 1H, J = 5.2 Hz), 7.45 (m, 1H), 7.22 (m, 1H).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 60
[2] Patent: WO2010/25451, 2010, A2. Location in patent: Page/Page column 50
[3] Patent: US2011/54173, 2011, A1. Location in patent: Page/Page column 30
[4] Patent: WO2011/25505, 2011, A1. Location in patent: Page/Page column 64
[5] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145

2-FLUOROISONICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUOROISONICOTINONITRILE Suppliers

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View Lastest Price from 2-FLUOROISONICOTINONITRILE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-FLUOROISONICOTINONITRILE 3939-14-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

3939-14-8, 2-FLUOROISONICOTINONITRILERelated Search:

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile 2-Cyano-6-fluoropyridine 3-Cyano-2-fluoropyridine N-Benzyloxycarbonyl-(2S,4R)-2-cyano-4-fluoropyrrolidine 2-Cyano-5-fluoropyridine 5-Cyano-2-fluoropyridine 2-Cyano-3-fluoropyridine 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE 2-FLUOROISONICOTINONITRILE 2,6-DIFLUORO-4-CYANO-PYRIDINE

4-Cyano-2-fluoropyridine, 2-Fluoropyridine-4-carbonitrile

2-cyano-2-fluoro-1,2-dihydropyridine-4-carboxylic acid

2-fluoro-4-Pyridinecarbonitrile

4-Cyano-2-fluoropyridine, 97%, 97%

2-fluoropyridine-4-carbonitrile

4-Pyridinecarbonitrile, 2-fluoro-

2-FLUOROISONICOTINONITRILE

2-Fluoroisonicotinonitrile 98%

2-Fluoroisonicotinonitrile98%

4-CYANO-2-FLUOROPYRIDINE

4-Cyano-2-fluoroyridine

2-FLUOROISONICOTINONITRILE ISO 9001：2015 REACH

3939-14-8

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