ChemicalBook > CAS DataBase List > CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

Product Name
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
CAS No.
215923-54-9
Chemical Name
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
Synonyms
GR 87;BDP 17;CX-546;BDP-17,CX546,GR87;CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P;1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine;1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine;(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone;2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone;Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-
CBNumber
CB7972429
Molecular Formula
C14H17NO3
Formula Weight
247.29
MOL File
215923-54-9.mol
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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Property

Melting point:
71-73°C
Boiling point:
422.8±44.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
pka
-1.08±0.20(Predicted)
form 
solid
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C271
Product name
CX546
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$277
Updated
2024/03/01
Sigma-Aldrich
Product number
C271
Product name
CX546
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$395.6
Updated
2024/03/01
Sigma-Aldrich
Product number
5.05016
Product name
CX546 - CAS 215923-54-9 - Calbiochem
Packaging
10MG
Price
$188
Updated
2022/05/15
Tocris
Product number
2980
Product name
CX546
Purity
≥99%(HPLC)
Packaging
10
Price
$150
Updated
2021/12/16
Tocris
Product number
2980
Product name
CX546
Purity
≥99%(HPLC)
Packaging
50
Price
$585
Updated
2021/12/16
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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Chemical Properties,Usage,Production

Uses

It is one of a series of AMPA modulators matergic AMPA receptors.

Uses

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

General Description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Biological Activity

AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

storage

Store at +4°C

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Preparation Products And Raw materials

Raw materials

Preparation Products

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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Suppliers

Canada 1 China 67 India 1 Switzerland 1 United Kingdom 2 United States 16 Global 88
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P manufacturers

Career Henan Chemical Co
Product
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P 215923-54-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

215923-54-9, CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)PRelated Search:

3-Methylpiperidin-3-ol HCl 4-ETHOXY-N,N-DIETHYLBENZAMIDE 3-ethoxy-N,N-diethyl-4-hydroxybenzamide CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P CHEMBRDG-BB 5762406

  • 1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine
  • 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
  • CX-546
  • BDP-17,CX546,GR87
  • Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-
  • CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
  • (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)Methanone
  • (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
  • BDP 17
  • GR 87
  • (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylMethanone CX 546
  • 2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
  • inhibit,CX-546,Autophagy,CX546,Inhibitor,CX 546,Ionotropic glutamate receptors,iGluR
  • 215923-54-9
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • AMPA receptor potentiator which is specifically bound to agonist bound non-desensitized receptors.