ChemicalBook > CAS DataBase List > D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)

Product Name
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
CAS No.
2647442-13-3
Chemical Name
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
Synonyms
GS-621763;VV116 (non-deuterated);GS-621763, 10 mM in DMSO;SARS-CoV,GS-621763,GS 621763,Inhibitor,SARS coronavirus,inhibit,GS621763;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate);(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate);(2R,3R,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(2-methylpropanoyloxy)tetrahydrofuran-2-yl]methyl 2-methylpropanoate
CBNumber
CB79752006
Molecular Formula
C24H31N5O7
Formula Weight
501.53
MOL File
2647442-13-3.mol
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D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Property

Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
4°C, away from moisture and light
solubility 
DMSO: 2mg/mL, clear
form 
Solid
pka
4.11±0.30(Predicted)
color 
White to off-white
InChIKey
RVSSLHFYCSUAHY-BSVPRABPNA-N
SMILES
C([C@@]1(C2=CC=C3C(=NC=NN23)N)O[C@H](COC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H]1OC(=O)C(C)C)#N |&1:1,13,21,28,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3571
Product name
GS-621763
Purity
≥98% (HPLC)
Packaging
5MG
Price
$175.75
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3571
Product name
GS-621763
Purity
≥98% (HPLC)
Packaging
25MG
Price
$741
Updated
2025/07/31
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D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Chemical Properties,Usage,Production

Uses

GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2[1][2].

Biological Activity

GS-621763 is an orally bioavailable analog of remdesivir, which is efficiently converted in plasma to active metabolite GS-441524, or in lungs to the bioactive triphosphate GS-443902. GS-621763 effectively reduces SARS-CoV-2 burden to near-undetectable levels in ferrets.

in vivo

GS-621763 (30 and 60 mg/kg p.o., twice daily for 4 days) shows potent antiviral activity in SARS-CoV-2 infected BALB/c mouse model[1]. GS-621763 (10 mg/kg, p.o., twice daily for 4 days) shows significant antiviral activity in SARS-CoV-2-infected ferret model[2].

Animal Model:SARS-CoV-2 infected BALB/c mouse model[1]
Dosage:30 mg/kg and 60 mg/kg
Administration:Oral gavage (p.o.), twice daily for 4 days
Result:Significantly reduced lung infectious virus levels (30 mg/kg); Further reduced ung infectious virus levels (60 mg/kg).
Animal Model:SARS-CoV-2-infected ferret model[2]
Dosage:10 mg/kg
Administration:Oral gavage (p.o.), twice daily for 4 days
Result:Significantly reduced SARS-CoV-2 shedding, with virus undetectable in nasal lavages.

References

[1] Sch?fer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111. DOI:10.1101/2021.09.13.460111
[2] Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12(1):6415. DOI:10.1038/s41467-021-26760-4

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Suppliers

China 32 United States 2 Global 34
Aladdin Scientific
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Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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2647442-13-3, D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)Related Search:


  • GS-621763
  • SARS-CoV,GS-621763,GS 621763,Inhibitor,SARS coronavirus,inhibit,GS621763
  • VV116 (non-deuterated)
  • (2R,3R,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(2-methylpropanoyloxy)tetrahydrofuran-2-yl]methyl 2-methylpropanoate
  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
  • GS-621763, 10 mM in DMSO
  • (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)
  • 2647442-13-3