ChemicalBook > CAS DataBase List > 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-
- Product Name
- 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-
- CAS No.
- 2094893-05-5
- Chemical Name
- 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-
- Synonyms
- EN523;EN523, 10 mM in DMSO;4-Acryloyl-1-(5-methyl-2-furyl)piperazin-2-one;4-Acryloyl-1-(5-methylfuran-2-yl)piperazin-2-one;1-(5-methylfuran-2-yl)-4-(prop-2-enoyl)piperazin-2-one;2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-;inhibit,EN-523,Inhibitor,non-catalytic,EN523,OTUB1 recruiter,EN 523,deubiquitinase,allosteric cysteine C23
- CBNumber
- CB810744792
- Molecular Formula
- C12H14N2O3
- Formula Weight
- 234.25
- MOL File
- 2094893-05-5.mol
More
Less
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Property
- Boiling point:
- 529.6±50.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 250 mg/mL (1067.24 mM; Need ultrasonic)
- pka
- -0.21±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C12H14N2O3/c1-3-10(15)13-6-7-14(11(16)8-13)12-5-4-9(2)17-12/h3-5H,1,6-8H2,2H3
- InChIKey
- KYXPDOMFYBFXKO-UHFFFAOYSA-N
- SMILES
- N1(C2=CC=C(C)O2)CCN(C(=O)C=C)CC1=O
More
Less
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Chemical Properties,Usage,Production
Uses
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].
Biological Activity
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].
References
[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421.
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Suppliers
- Tel
- 0371-53399770 18037166334
- 2853031800@qq.com
- Country
- China
- ProdList
- 5857
- Advantage
- 58
- Tel
- 021-38681880 13817889927
- Fax
- 0213390-8196
- sales@synmedia-chem.com
- Country
- China
- ProdList
- 249
- Advantage
- 58
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 13816613772
- Fax
- QQ: 12922499
- huahero21@sina.com
- Country
- China
- ProdList
- 2390
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- 13504435624
- 1927928688@qq.com
- Country
- China
- ProdList
- 1615
- Advantage
- 58
- Tel
- 020-82000279 18988941452
- Fax
- QQ：3283937693
- YN_research@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 15317229551
- Fax
- QQ:3607245178
- 15151849396@163.com
- Country
- China
- ProdList
- 989
- Advantage
- 58
- Tel
- 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 2995
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62220
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 025-58859352 18921922613
- hywu@aikonchem.com
- Country
- China
- ProdList
- 10710
- Advantage
- 58
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
- Country
- China
- ProdList
- 2742
- Advantage
- 58
- Tel
- 13186333400
- cuichengbio@163.com
- Country
- China
- ProdList
- 4845
- Advantage
- 58
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 6614
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29995
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 18682931470; 18682931470
- 2142355700@qq.com
- Country
- China
- ProdList
- 4723
- Advantage
- 58
- Tel
- 17721492509; 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 4976
- Advantage
- 58
- Tel
- 17316404525 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 15666167041
- 15666167041@163.com
- Country
- China
- ProdList
- 2994
- Advantage
- 58
- Tel
- 028-81700200 13308200041
- 2851167782@qq.com
- Country
- China
- ProdList
- 11146
- Advantage
- 58
- Tel
- 400-821-026
- Sales@sangon.com
- Country
- China
- ProdList
- 6710
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- +8613720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5221
- Advantage
- 58
- Tel
- +undefined18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 3135
- Advantage
- 58
- Tel
- 13128698830
- Country
- CHINA
- ProdList
- 181
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- Proteintech-CN@ptglab.com
- Country
- CHINA
- ProdList
- 6290
- Advantage
- 58