2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-

Product Name: 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-
CAS No.: 2094893-05-5
Chemical Name: 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-
Synonyms: EN523;EN523, 10 mM in DMSO;4-Acryloyl-1-(5-methyl-2-furyl)piperazin-2-one;4-Acryloyl-1-(5-methylfuran-2-yl)piperazin-2-one;1-(5-methylfuran-2-yl)-4-(prop-2-enoyl)piperazin-2-one;2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-;inhibit,EN-523,Inhibitor,non-catalytic,EN523,OTUB1 recruiter,EN 523,deubiquitinase,allosteric cysteine C23
CBNumber: CB810744792
Molecular Formula: C12H14N2O3
Formula Weight: 234.25
MOL File: 2094893-05-5.mol

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2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Property

Boiling point:: 529.6±50.0 °C(Predicted)
Density: 1.225±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (1067.24 mM; Need ultrasonic)
pka: -0.21±0.20(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C12H14N2O3/c1-3-10(15)13-6-7-14(11(16)8-13)12-5-4-9(2)17-12/h3-5H,1,6-8H2,2H3
InChIKey: KYXPDOMFYBFXKO-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(C)O2)CCN(C(=O)C=C)CC1=O

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Hazard and Precautionary Statements (GHS)

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2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Chemical Properties,Usage,Production

Uses

EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].

Biological Activity

EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].

References

[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421.

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Suppliers

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2094893-05-5, 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-Related Search:

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-

EN523

inhibit,EN-523,Inhibitor,non-catalytic,EN523,OTUB1 recruiter,EN 523,deubiquitinase,allosteric cysteine C23

4-Acryloyl-1-(5-methyl-2-furyl)piperazin-2-one

1-(5-methylfuran-2-yl)-4-(prop-2-enoyl)piperazin-2-one

EN523, 10 mM in DMSO

4-Acryloyl-1-(5-methylfuran-2-yl)piperazin-2-one

2094893-05-5