ChemicalBook > CAS DataBase List > 3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)

3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)

Product Name: 3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)
CAS No.: 2311824-72-1
Chemical Name: 3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)
Synonyms: Ninerafaxstat 3HCl;IMB-101 trihydrochloride);Ninerafaxstat trihydrochloride;Ninerafaxstat trihydrochloride, 10 mM in DMSO;Ninerafaxstat trihydrochloride (MB-1018972 trihydrochloride;2-(4-(2,3,4-Trimethoxybenzyl)piperazin-1-yl)ethyl nicotinate trihydrochloride;2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethyl nicotinate,hydrogen chloride;2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)
CBNumber: CB812110140
Molecular Formula: C22H30ClN3O5
Formula Weight: 451.95
MOL File: 2311824-72-1.mol

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3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3) Property

form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3) Chemical Properties,Usage,Production

Uses

Ninerafaxstat trihydrochloride (IMB-1018972 trihydrochloride) is the trihydrochloride salt form of Ninerafaxstat (HY-139577). Ninerafaxstat trihydrochloride is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat trihydrochloride can be used for research on cardiovascular diseases[1][2].

in vivo

Ninerafaxstat trihydrochloride (30 mg/kg; once daily; 4 weeks; via osmotic minipump) can improve left ventricular systolic function and reduce left ventricular end diastolic pressure (LVEDP) and myocardial fibrosis in a mouse model of heart failure after myocardial infarction^[2].

Animal Model:	Murine model of post-MI HF^[2].
Dosage:	30 mg/kg
Administration:	Via osmotic minipump; once daily; 4 weeks
Result:	Increased left ventricular ejection fraction (LVEF) and reduced cardiac fibrosis.

References

[1] Moritz Hundertmark MD, et al. Kiosk 11R-TC-08 - Ninerafaxstat Modulates Cardiac Energy Metabolism in Cardio-metabolic Syndromes: A Mechanistic, Hyperpolarized MR Trial. Journal of Cardiovascular Magnetic Resonance. 2024; 26: 100325.
[2] Paul Chamberlin, et al. IMB-1018792, A NOVEL FIRST-IN CLASS PARTIAL FATTY ACID OXIDATION INHIBITOR IMPROVES CARDIAC REMODELING AND FUNCTION POST-MYOCARDIAL INFARCTION. J Am Coll Cardiol. 2021 May 11;77(18):539.

3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3) Preparation Products And Raw materials

Raw materials

Preparation Products

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2311824-72-1, 3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)Related Search:

3-Pyridinecarboxylic acid, 2-[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]ethyl ester, hydrochloride (1:3)

Ninerafaxstat trihydrochloride

Ninerafaxstat 3HCl

2-(4-(2,3,4-Trimethoxybenzyl)piperazin-1-yl)ethyl nicotinate trihydrochloride

IMB-101 trihydrochloride)

Ninerafaxstat trihydrochloride (MB-1018972 trihydrochloride

Ninerafaxstat trihydrochloride, 10 mM in DMSO

2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethyl nicotinate,hydrogen chloride

2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate

2311824-72-1