ChemicalBook > CAS DataBase List > ALK-IN-27

ALK-IN-27

Product Name: ALK-IN-27
CAS No.: 2739866-40-9
Chemical Name: ALK-IN-27
Synonyms: ALK-IN-27;Neladalkib;Neladalkib (NVL-655);Neladalkib (Synonyms: NVL-655);(R)-1-chloro-3-ethyl-12-fluoro-10,16-dimethyl-3,10,16,18-tetrahydro-4,8-(metheno)benzo[l]dipyrazolo[3,4-g:4',3'-j][1]oxa[4]azacyclotetradecin-7-amine;(19R)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,?.0?,12.013,1?]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine
CBNumber: CB813765583
Molecular Formula: C23H22ClFN6O
Formula Weight: 452.91
MOL File: 2739866-40-9.mol

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ALK-IN-27 Property

Boiling point:: 685.0±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka: 7.11±0.40(Predicted)
form: Solid
color: White to off-white
InChIKey: FWZSCAQEBTVTOM-GFCCVEGCSA-N
SMILES: C(N1N=C(C2CC3=CN(N=C3C3=CC=C(C=C3[C@H](OC3=C(N=CC(=C3)C=21)N)C)F)C)Cl)C

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Hazard and Precautionary Statements (GHS)

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ALK-IN-27 Chemical Properties,Usage,Production

Uses

Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity[1][2].

in vivo

Neladalkib (0.06-1.5 mg/kg, orally, twice daily, days 0-28) has antitumor activity in mice^[2].

Animal Model:	ALK-driven tumor xenografts in mice^[2]
Dosage:	0.06, 0.2, 0.5, 1.5 mg/kg
Administration:	Oral
Result:	Inhibited tumor proliferation.

References

[1] Jennifer Anne Green, et al. Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine. WO2023196910A1.
[2] Jessica J Lin, et al. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discov. 2024 Sep 13:OF1-OF20. DOI:10.1158/2159-8290.CD-24-0231

ALK-IN-27 Preparation Products And Raw materials

Raw materials

Preparation Products

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2739866-40-9, ALK-IN-27Related Search:

ALK-IN-27

(R)-1-chloro-3-ethyl-12-fluoro-10,16-dimethyl-3,10,16,18-tetrahydro-4,8-(metheno)benzo[l]dipyrazolo[3,4-g:4',3'-j][1]oxa[4]azacyclotetradecin-7-amine

(19R)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,?.0?,12.013,1?]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine

Neladalkib (Synonyms: NVL-655)

Neladalkib (NVL-655)

Neladalkib

2739866-40-9