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apratastat

Product Name
apratastat
CAS No.
287405-51-0
Chemical Name
apratastat
Synonyms
TMI 005;apratastat;TMI 005 - Apratastat;Apratastat >=98% (HPLC);N-hydroxy-4-[[4-[(4-hydroxy-2-butynyl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide;3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)-
CBNumber
CB81508587
Molecular Formula
C17H22N2O6S2
Formula Weight
414.5
MOL File
287405-51-0.mol
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apratastat Property

Density 
1.390
storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
9.25±0.23(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1543
Product name
Apratastat
Purity
≥98% (HPLC)
Packaging
5MG
Price
$201
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1543
Product name
Apratastat
Purity
≥98% (HPLC)
Packaging
25MG
Price
$636
Updated
2023/06/20
Cayman Chemical
Product number
29016
Product name
TMI-005
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
29016
Product name
TMI-005
Packaging
10mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
29016
Product name
TMI-005
Packaging
5mg
Price
$183
Updated
2024/03/01
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apratastat Chemical Properties,Usage,Production

Uses

Treatment of rheumatoid arthritis.

Definition

ChEBI: Apratastat is a sulfonamide.

brand name

(Wyeth).

Biological Activity

Apratast at (TMI-005) is an orally active, potent and selective dual inhibitor of disintegrin metalloenzyme 17 (ADAM17/ TACE) and matrix metalloprotease (MMP).

apratastat Preparation Products And Raw materials

Raw materials

Preparation Products

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apratastat Suppliers

China 18 The Netherlands 1 United States 8 Global 27
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

287405-51-0, apratastatRelated Search:


  • apratastat
  • TMI 005 - Apratastat
  • N-hydroxy-4-[[4-[(4-hydroxy-2-butynyl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide
  • TMI 005
  • 3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)-
  • Apratastat >=98% (HPLC)
  • 287405-51-0