apratastat

Product Name: apratastat
CAS No.: 287405-51-0
Chemical Name: apratastat
Synonyms: TMI 005;apratastat;TMI 005 - Apratastat;Apratastat >=98% (HPLC);N-hydroxy-4-[[4-[(4-hydroxy-2-butynyl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide;3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)-
CBNumber: CB81508587
Molecular Formula: C17H22N2O6S2
Formula Weight: 414.5
MOL File: 287405-51-0.mol

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apratastat Property

Density: 1.390
storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
pka: 9.25±0.23(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1543
Product name: Apratastat
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $201
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1543
Product name: Apratastat
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $636
Updated: 2023/06/20

Cayman Chemical

Product number: 29016
Product name: TMI-005
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29016
Product name: TMI-005
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 29016
Product name: TMI-005
Packaging: 5mg
Price: $183
Updated: 2024/03/01

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apratastat Chemical Properties,Usage,Production

Uses

Treatment of rheumatoid arthritis.

Definition

ChEBI: Apratastat is a sulfonamide.

brand name

(Wyeth).

Biological Activity

Apratast at (TMI-005) is an orally active, potent and selective dual inhibitor of disintegrin metalloenzyme 17 (ADAM17/ TACE) and matrix metalloprotease (MMP).

apratastat Preparation Products And Raw materials

Raw materials

Preparation Products

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apratastat Suppliers

China 18 The Netherlands 1 United States 8 Global 27

BOC Sciences

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Cayman Chemical Company

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MedChemExpress

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Axon Medchem LLC

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International Laboratory Limited

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Syncom BV

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287405-51-0, apratastatRelated Search:

apratastat

TMI 005 - Apratastat

N-hydroxy-4-[[4-[(4-hydroxy-2-butynyl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide

TMI 005

3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)-

Apratastat >=98% (HPLC)

287405-51-0