1-METHYL-1H-INDOL-4-AMINE

Product Name: 1-METHYL-1H-INDOL-4-AMINE
CAS No.: 85696-95-3
Chemical Name: 1-METHYL-1H-INDOL-4-AMINE
Synonyms: 1-methylindol-4-amine;1-methyl-4-indolamine;4-Amino-1-methylindole;4-AMINO-N-METHYLINDOLE;1-METHYL-1H-INDOL-4-AMINE;1-METHYL-1H-INDOLE-4-AMINE;1H-Indol-4-amine, 1-methyl-;1-METHYL-1H-INDOL-4-YLAMINE
CBNumber: CB8167042
Molecular Formula: C9H10N2
Formula Weight: 146.19
MOL File: 85696-95-3.mol

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1-METHYL-1H-INDOL-4-AMINE Property

Boiling point:: 328.0±15.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.04±0.10(Predicted)
form: solid
Appearance: Brown to black Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M321575
Product name: 1-Methyl-1H-indol-4-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0061752
Product name: 1-Methyl-1H-indol-4-amine
Purity: 99.56%
Packaging: 100mg
Price: $91
Updated: 2021/12/16

ChemScene

Product number: CS-0061752
Product name: 1-Methyl-1H-indol-4-amine
Purity: 99.56%
Packaging: 250mg
Price: $143
Updated: 2021/12/16

Apolloscientific

Product number: OR913289
Product name: 4-Amino-N-methylindole
Purity: 97%
Packaging: 1g
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: X4949
Product name: 1-Methyl-1H-indol-4-ylamine
Packaging: 100mg
Price: $257
Updated: 2021/12/16

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1-METHYL-1H-INDOL-4-AMINE Chemical Properties,Usage,Production

Synthesis

91482-63-2

85696-95-3

General procedure for the synthesis of 4-amino-N-methylindole from 1-methyl-4-nitro-1H-indole: Reduced iron powder (3.36 g, 60 mmol) was added batchwise to a boiling mixture containing 1-methyl-4-nitro-1H-indole (40 mmol), concentrated hydrochloric acid (5 mL) and ethanol (100 mL). The resulting suspension was refluxed for 1 h. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with ammonia, filtered to remove iron residue, and washed with ethanol (30 mL). The filtrate was evaporated and concentrated, then diluted with ethyl acetate (100 mL). The organic phase was washed sequentially with brine (25 mL) and water (2 x 50 mL), dried with magnesium sulfate, and the solvent was evaporated to give the residue 1-methyl-1H-indol-4-ylamine (7). The product was a gray solid with a melting point of 95-96 °C in 85% yield.1H NMR (300 MHz, CDCl3) δ 7.02 (t, 1H, J = 7.8 Hz, H-6), 6.86 (d, 1H, J = 3.3 Hz, H-2), 6.74 (d, 1H, J = 8.7 Hz, H-5), 6.33 (d, 1H, J = 8.7 Hz , H-7), 6.32 (d, 1H, J = 3.3 Hz, H-3), 3.82 (br s, 2H, NH2-4), 3.61 (s, 3H, CH3-1). Calculated values for elemental analysis (C9H10N2): C, 73.94; H, 6.89; N, 19.16; measured values: C, 73.80; H, 6.80; N, 19.30%.

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 871 - 887
[2] Tetrahedron Letters, 2017, vol. 58, # 13, p. 1324 - 1325
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3417 - 3427
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 8, p. 1104 - 1107
[5] Patent: US2009/227575, 2009, A1. Location in patent: Page/Page column 21; 17

1-METHYL-1H-INDOL-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-1H-INDOL-4-AMINE Suppliers

China 71 Germany 1 India 2 United Kingdom 2 United States 15 Global 91

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View Lastest Price from 1-METHYL-1H-INDOL-4-AMINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-amino-1-methylindole 85696-95-3
Price: US $1.60-9.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-20

Career Henan Chemical Co

Product: 1-methylindol-4-amine 85696-95-3
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

85696-95-3, 1-METHYL-1H-INDOL-4-AMINERelated Search:

5-METHOXY-1-METHYL-4-NITROINDOLE-3-CARBOXALDEHYDE 1-BOC-4-AMINOINDOLE 1-METHYL-1H-INDOL-4-AMINE 3-Methyl-1H-indol-1-amine 1-METHYL-1H-INDOL-5-AMINE 2,3-Dihydro-2-methyl-1H-indol-1-amine hydrochloride 2,3-dihydro-2-methyl-1h-indol-1-amine 2-METHYL-1H-INDOL-5-AMINE 1-Methylindole (4-TERT-BUTOXYCARBONYLAMINO-INDOL-1-YL)-ACETIC ACID 4-AMINO-5-METHOXY-1,2-DIMETHYL-1H-INDOLE-3-CARBOXYLIC ACID ETHYL ESTER 4-[1-(4-TERT-BUTOXYCARBONYL-BENZYL)-1H-INDOL-4-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-(4-TERT-BUTOXYCARBONYLAMINO-INDOL-1-YL)-PROPIONIC ACID 3-ethyl-2-methyl-1H-indol-5-amine 2,3-dihydro-2-methyl-1H-indol-1-amine monomethanesulphonate 1-ETHYL-2-METHYL-1H-INDOL-5-AMINE RARECHEM AL BL 1482 RARECHEM AL BD 1521

4-AMINO-N-METHYLINDOLE

1-METHYL-1H-INDOL-4-AMINE

1-METHYL-1H-INDOL-4-YLAMINE

1-METHYL-1H-INDOLE-4-AMINE

1H-Indol-4-amine, 1-methyl-

1-methylindol-4-amine

4-Amino-1-methylindole

1-methyl-4-indolamine

85696-95-3

Indole