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Paroxetine hydrochloride

Product Name
Paroxetine hydrochloride
CAS No.
78246-49-8
Chemical Name
Paroxetine hydrochloride
Synonyms
FG-7051;Deroxat;Seroxat;brl29060a;BRL-29060;(3s,4r)-orid;(3s-trans)-id;PAROXETINE HC;PAROXETINE HCL;PAROXETIN X HCL
CBNumber
CB8178022
Molecular Formula
C19H21ClFNO3
Formula Weight
365.83
MOL File
78246-49-8.mol
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Paroxetine hydrochloride Property

Melting point:
129-131°C
storage temp. 
2-8°C
form 
neat
CAS DataBase Reference
78246-49-8(CAS DataBase Reference)
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Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1804
Product name
Paroxetine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500 mg
Price
$173
Updated
2021/03/22
Sigma-Aldrich
Product number
Y0000578
Product name
Paroxetine hydrochloride (anhydrous)
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000578
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
1500218
Product name
Paroxetine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
350 mg
Price
$366
Updated
2021/03/22
Cayman Chemical
Product number
14998
Product name
Paroxetine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$39
Updated
2021/03/22
Cayman Chemical
Product number
14998
Product name
Paroxetine (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$93
Updated
2021/03/22
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Paroxetine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Powder

Originator

Paxil, SmithKline Beecham ,France

Uses

Paroxetine is an antidepressant drug of the SSRI type

Uses

A selective serotonin reuptake inhibitor. Used as an antidepressant

Manufacturing Process

251 g of methyl-4-(4-fluorophenyl)-N-methyl-nipecotinate, 8 g of sodium methoxide and 500 ml benzene were refluxed for 2 h. The benzene solution was washed with cold water and evaporated to give the pure α-ester which was dissolved in a mixture of 320 ml of water and 450 ml concentrated hydrochloric acid. The solution was slowly distilled to remove methanol and finally evaporated to dryness in vacuo.
400 ml thionyl chloride were added in small portions to the solid. The mixture was allowed to stand for 3 h at room temperature and was then evaporated to dryness in vacuo with tetrachloroethane giving methyl-4-(4-fluorophenyl)-Nmethylnipecotic acid chloride. The acid chloride was added in small portions to a solution of 160 g (-)-menthol in 800 ml pyridine at a temperature of 0°-5°C. The mixture was allowed to stand at room temperature to the next day. Ice water and 50% sodium hydroxide were added, and the mixture was extracted with ether. The ether was dried with anhydrous magnesium sulphate, filtered and evaporated. Distillation in vacuo gave the menthol ester in a yield of 7580%. Boiling point at 0.05 mm Hg was 165°-170°C.
Racemic 4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (50 g) was dissolved in a mixture of 21.6 ml of concentrated sulfuric acid and 50 ml of water. To the solution were added 25 ml of concentrated hydrochloric acid and 22.4 ml of 37% formaldehyde solution. The mixture was refluxed for 5 h, cooled, and 125 ml of concentrated ammonia were added. The mixture was extracted with 50 ml of toluene. Drying of the toluene solution and distillation gave 38 g of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine with boiling point 110°-120°C at 0.1 mm Hg.
13 g of the racemic compound and 22 g of (-)-dibenzoyltartaric acid were dissolved in 105 ml of hot methanol. On cooling, 9 g of salt of (-)-4-(4fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6-tetrahydropyridine crystallized. Melting point 167°-168°C.
38 g of (-)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine were dissolved in 350 ml of 99% ethanol, 5 g of 5% palladium on carbon were added, and the mixture was treated with hydrogen until 4500 ml were absorbed. The catalyst was filtered off, and the solution was evaporated to yield 37.5 g of (+)-b-4-(4-fluorophenyl)-3-hydroxymethyl1-methylpiperidine.
To a solution of sodium in methanol (125 ml) were added 3,4methylenedioxyphenol (29 g) and the (+)-b-4-(4-fluorophenyl)-3hydroxymethyl-1-methylpiperidine (37,5 g). The mixture was stirred and refluxed. After removal of the solvent in vacuo, the evaporation residue was poured into a mixture of ice (150 g), water (150 ml), and ether (200 ml). The ether layer was separated, and the aqueous layer was extracted with ether. The combined ether solutions were washed with water and dried with anhydrous magnesium sulphate, and the ether was evaporated. The residue was triturated with 200 ml of 99% ethanol and 11.5 ml of concentrated hydrochloric acid, yielding 30 g of (-)-b-4-(4-fluorophenyl-3-(1,3-benzdioxolyl(3)-oxymethyl)-1-methylpiperidine, hydrochloride were obtained. Melting point 202°C.

brand name

Paxil (GlaxoSmithKline).

Therapeutic Function

Antidepressant

Paroxetine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Paroxetine hydrochloride Suppliers

Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
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62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
MedChemexpress LLC
Tel
609-228-6898
Fax
609-228-5909
Email
sales@medchemexpress.com
Country
United States
ProdList
4787
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2773
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10657
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60
Target Molecule Corp
Tel
781-999-5354
Email
marketing@targetmol.com
Country
United States
ProdList
19232
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58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14344
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58
BOC Sciences
Tel
1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19752
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View Lastest Price from Paroxetine hydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Paroxetine hydrochloride
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-01-14
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Paroxetine hydrochloride 78246-49-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-08
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Paroxetine hydrochloride 78246-49-8
Price
US $600.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2020-11-02

78246-49-8, Paroxetine hydrochlorideRelated Search:


  • PAROMOMYCINSULFATE
  • (3s,4r)-orid
  • (3s-trans)-id
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,hydrochloride,(3s-trans)-piperidin
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidinhydrochl
  • PAROXETINE HC
  • Paroxetine hydrochloride,trans-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride
  • (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride hemihydrate
  • 5-[[(3S,4R)-4-(4-Fluorophenyl)-3-piperidyl]methoxy]-1,3-benzodioxole·hydrochloride
  • 3-[(1,3-benzodioxol-5-yloxy)meth
  • Paroetine Hydrochloride HeMihydrate
  • (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)Methyl)-4-(4-fluorophenyl)piperidine hydrochloride
  • Paroxetine HCl heMihydrate API
  • Proxetine Hydrochloride
  • Paroxetine HCl Anhydrous
  • (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine, hydrochloride (1:1)
  • Paroxetine HCL USP37
  • Paroxetine hydrochloride, 99%, a selective serotonin-reuptake inhibitor
  • BRL29060 HYDROCHLORIDE;BRL29060A
  • (110429-35-1) paroxetine hydrochloride
  • 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidinhydrochlor
  • brl29060a
  • brl29060hydrochloride
  • BRL-29060
  • FG-7051
  • (3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE
  • (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride
  • PAROXETINE HCL
  • PAROXETINE HYDROCHLORIDE
  • PAROXETIN X HCL
  • (-)TRANS-3-[(1,3-BENZODIOXOL-5-YLOXY) METHYL]-4-(4-FLUOROPHENYL) PAROXETINE HYDROCHLORIDE
  • Paroxetine HCL EP4.5
  • Paroxeting chlorhydric acid
  • ParoxetineHCl.1/2H2O
  • (-)TRANS-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE HYDROCHLORIDE
  • Deroxat
  • Seroxat
  • Piperidine, 3-(1,3-benzodioxol-5-yloxy)methyl-4-(4-fluorophenyl)-, hydrochloride, (3S,4R)-
  • Paroxetine Hydrochloride RS
  • Paroxetine hydrochloride hemihydrate CRS
  • Paroxetine hydrochloride USP/EP/BP
  • 78246-49-8
  • C19H20NO3FHCl
  • C19H20FNO3ClH
  • C19H21ClFNO3
  • C19H20FNO3HClC19H21ClFNO3
  • C20H21FNO3
  • C19H20FNO3HCl
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's
  • Serotonin receptor