ChemicalBook > CAS DataBase List > 2-Picolinic acid

2-Picolinic acid

Product Name
2-Picolinic acid
CAS No.
98-98-6
Chemical Name
2-Picolinic acid
Synonyms
PICOLINIC ACID;PYRIDINE-2-CARBOXYLIC ACID;2-PYRIDINECARBOXYLIC ACID;Pyridine-2-carboxylic;PCL 016;Picolonic acid;2-Carboxypyridine;ALPHA-PICOLINIC ACID;2-Pyridinecarboxylic;2-PicoL
CBNumber
CB8196640
Molecular Formula
C6H5NO2
Formula Weight
123.11
MOL File
98-98-6.mol
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2-Picolinic acid Property

Melting point:
139-142 °C (lit.)
Boiling point:
229.19°C (rough estimate)
Density 
1.3147 (rough estimate)
bulk density
500-700kg/m3
vapor pressure 
0.028Pa at 25℃
refractive index 
1.5423 (estimate)
Flash point:
139°(232°F)
storage temp. 
Store below +30°C.
solubility 
H2O: 50 mg/mL, clear
pka
1.07(at 25℃)
form 
Crystalline Powder
color 
White to almost white
PH
3.1 (50g/l, H2O, 20℃)
Water Solubility 
887 g/L (20 ºC)
Merck 
14,7403
BRN 
109595
InChIKey
SIOXPEMLGUPBBT-UHFFFAOYSA-N
LogP
0.72
CAS DataBase Reference
98-98-6(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridinecarboxylic acid(98-98-6)
EPA Substance Registry System
2-Pyridinecarboxylic acid (98-98-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36-36/37/38
Safety Statements 
26-36-33-24/25
WGK Germany 
3
RTECS 
TJ7344000
TSCA 
Yes
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P42800
Product name
2-Picolinic acid
Purity
ReagentPlus , 99%
Packaging
5g
Price
$49.4
Updated
2025/07/31
Sigma-Aldrich
Product number
P42800
Product name
2-Picolinic acid
Purity
ReagentPlus , 99%
Packaging
100g
Price
$80.9
Updated
2025/07/31
Sigma-Aldrich
Product number
8.00735
Product name
2-Pyridinecarboxylic acid
Purity
for synthesis
Packaging
100g
Price
$76.3
Updated
2022/05/15
TCI Chemical
Product number
P0421
Product name
Pyridine-2-carboxylic Acid
Purity
>99.0%(T)
Packaging
25g
Price
$22
Updated
2025/07/31
TCI Chemical
Product number
P0421
Product name
Pyridine-2-carboxylic Acid
Purity
>99.0%(T)
Packaging
100g
Price
$53
Updated
2025/07/31
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2-Picolinic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white to tan powder. easily soluble in glacial acetic acid, almost insoluble in ether, chloroform and carbon disulfide.

Uses

2-Picolinic acid is used as a chelate for alkaline earth metals. It is also used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.

Application

2-Picolinic acid is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.
Metal complexes of picolinic acid were prepared by the refluxion of metal salts and picolinic acid in ethanol taking 1:3 molar ratio for 6 hours. The solutions were concentrated and cooled, to crystallize out the complexes.The complexes were washed with ether to remove the excess ligand.

Definition

ChEBI: Picolinic acid is a pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan. It has a role as a MALDI matrix material and a human metabolite. It is a conjugate acid of a picolinate.

reaction suitability

reagent type: catalyst
reagent type: ligand
reaction type: C-H Activation

Synthesis

2-Picolinic acid synthesis: In a 500ml three-necked flask, add 100g of 2-cyanopyridine and 200g of deionized water, then start stirring, heat up to 50°C, add 128.2g of 30% sodium hydroxide to the flask, after adding, add Continue to heat up, react under reflux for 4 hours, then distill water, after 50 g of distilled water, cool the reaction solution to 20°C, add 30% hydrochloric acid, adjust the pH value of the reaction solution to 2.5, then turn on the steam to heat up the water and steam to the kettle When the temperature reaches 120°C, the reaction solution is evaporated to dryness, and the distilled water is completed. Then, 300 g of anhydrous alcohol is added dropwise to the flask to maintain the temperature of the reaction solution at 55°C. After cooling and crystallization, a solid was precipitated, filtered and dried to obtain 106.0 g of 2-picolinic acid with a yield of 89.6%.

Purification Methods

Crystallise the acid from water or *benzene. The picrate has m 185-187o (from MeOH). [Beilstein 22 H 33, 22 I 502, 22 II 30, 22 III/IV 303, 22/2 V 3.]

2-Picolinic acid Preparation Products And Raw materials

Raw materials

Congo Red Ethanol Manganese dioxide Potassium permanganate

Preparation Products

4-IODOPYRIDINE-2-CARBOXYLIC ACID 4-CHLORO-1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Pyridine-2-carbonyl chloride hydrochloride 2-Aminopyridin-4-ol 2-isocyanatopyridine 3-BROMOPYRIDINE-2-CARBOXYLIC ACID 2-Amino-4-chloropyridine 4-Chloropyridine-2-carboxamide PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
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View Lastest Price from 2-Picolinic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Picolinic acid 98-98-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-25
Jinan Finer Chemical Co., Ltd
Product
Picolinic acid 98-98-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
500mt/year
Release date
2021-07-27
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Picolinic acid 98-98-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-09-29

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