4-Bromo-3-nitroanisole

Product Name: 4-Bromo-3-nitroanisole
CAS No.: 5344-78-5
Chemical Name: 4-Bromo-3-nitroanisole
Synonyms: TIMTEC-BB SBB009974;4-Brom-3-nitroanisol;4-Bromo-3-nitroanisol;4-BROMO-3-NITROANISOLE;4-Bromo-3-nitroanlsole;4-BROMO-3-NITROTHIOANISOLE;4-Bromo-3-nitroanisole >4-bromo-3-nitrobenzyl ether;3-nitro-4-bromobenzyl ether;4-Methoxy-2-nitrobromobenzene
CBNumber: CB8211332
Molecular Formula: C7H6BrNO3
Formula Weight: 232.03
MOL File: 5344-78-5.mol

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4-Bromo-3-nitroanisole Property

Melting point:: 32-34 °C (lit.)
Boiling point:: 153-154 °C/13 mmHg (lit.)
Density: 1.8134 (rough estimate)
refractive index: 1.6090 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to lump to clear liquid
color: White or Colorles to Yellow to Orange
BRN: 2446617
InChI: InChI=1S/C7H6BrNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
InChIKey: KCOBIBRGPCFIGF-UHFFFAOYSA-N
SMILES: C1(Br)=CC=C(OC)C=C1[N+]([O-])=O
CAS DataBase Reference: 5344-78-5(CAS DataBase Reference)
NIST Chemistry Reference: 4-Bromo-3-nitroanisole(5344-78-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 338737
Product name: 4-Bromo-3-nitroanisole
Purity: 97%
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: B3420
Product name: 4-Bromo-3-nitroanisole
Purity: >96.0%(GC)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: B3420
Product name: 4-Bromo-3-nitroanisole
Purity: >96.0%(GC)
Packaging: 25g
Price: $127
Updated: 2025/07/31

TRC

Product number: B688138
Product name: 4-Bromo-3-nitroanisole
Packaging: 5g
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-W008002
Product name: 1-Bromo-4-methoxy-2-nitrobenzene
Packaging: 25g
Price: $30
Updated: 2021/12/16

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4-Bromo-3-nitroanisole Chemical Properties,Usage,Production

Chemical Properties

Yellow to dark brown solid

Uses

4-Bromo-3-nitroanisole was used in the synthesis of:

4-bromo-5-methoxyaniline
2-(4-methoxy-2-nitrophenylsulfanyl)benzoic acid
4-(1-diethylamino-4-pentylamino)-3-nitrochlorobenzene

General Description

FT-IR and FT-Raman spectra of 4-bromo-3-nitroanisole have been studied.

Synthesis

96-96-8

5344-78-5

The general procedure for the synthesis of 4-bromo-3-nitroanisole from ice-dyed diazo component 1 was as follows: a solution of sodium nitrite (11.8 g) in water (28 mL) was slowly added dropwise to a 40% solution of nitroaniline (125 mmol) in hydrobromic acid (110 g) over a period of 0.5 h. The temperature of the reaction was maintained at 10 °C. The reaction mixture was stirred at 0-10 °C for 40 min and then filtered. Subsequently, the filtrate was added dropwise to a purple solution of copper(I) bromide (209 mmol) in hydrobromic acid (74 mL) at 0 °C over a period of 1 hour. The reaction mixture was gradually warmed to room temperature and held for 30 min, then warmed to 60 °C for 0.5 h. The reaction was finally heated and refluxed for 1 h. The reaction was carried out at a temperature of 0.5 °F to 0.5 °F. After completion of the reaction, the mixture was partitioned between water (2.0 L) and dichloromethane (600 mL) and the aqueous phase was then extracted with dichloromethane (300 mL). All organic layers were combined and washed sequentially with 10% sodium hydroxide solution (200 mL), water (600 mL), 10% hydrochloric acid (300 mL) and water (600 mL). The organic layer was dried over magnesium sulfate and concentrated to give 4-bromo-3-nitroanisole in 83% yield as a yellow oil.

References

[1] Journal of Organic Chemistry, 1989, vol. 54, # 25, p. 5856 - 5866
[2] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6380 - 6382
[3] Journal of the American Chemical Society, 1994, vol. 116, # 26, p. 11797 - 11810
[4] Tetrahedron Letters, 2006, vol. 47, # 16, p. 2739 - 2742
[5] Tetrahedron, 2010, vol. 66, # 37, p. 7418 - 7422

4-Bromo-3-nitroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-nitroanisole Suppliers

Americas 1 China 207 Europe 3 France 1 Germany 5 India 21 Japan 1 Slovakia 1 Switzerland 1 The Netherlands 1 United Kingdom 13 United States 27 Global 282

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View Lastest Price from 4-Bromo-3-nitroanisole manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-Bromo-3-Nitroanisole 5344-78-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Bromo-3-nitroanisole 5344-78-5
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-12

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Bromo-3-nitroanisole 5344-78-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-30

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5344-78-5

Organic Building Blocks

Nitrogen Compounds

Nitro Compounds

Building Blocks

ARYL HALIDE

Phenyls & Phenyl-Het

Nitro Compounds

Nitrogen Compounds

Organic Building Blocks

blocks

Bromides

NitroCompounds

Halides

Phenyls & Phenyl-Het

Anisole

Anisoles, Alkyloxy Compounds & Phenylacetates

Bromine Compounds

Nitro Compounds