ChemicalBook > CAS DataBase List > 2-Fluoroisonicotinic acid
2-Fluoroisonicotinic acid
- Product Name
- 2-Fluoroisonicotinic acid
- CAS No.
- 402-65-3
- Chemical Name
- 2-Fluoroisonicotinic acid
- Synonyms
- uoroisonicotinic Acid;2-FluoroisonicotinicAci;2-Fluoroisonotinic acid;2-Fluoroisonictinic acid;2-FLUOROISONICOTINIC ACID;2-FluoroisonicotinicAcid>2-Fluoro-4-pyridinecorboxylc;2-Fluoroisonicotinic acid ,98%;2-Fluoro-4-pyridinecarboxlic acid;2-Fluoropyridin-4-carboxylic acid
- CBNumber
- CB8213068
- Molecular Formula
- C6H4FNO2
- Formula Weight
- 141.1
- MOL File
- 402-65-3.mol
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2-Fluoroisonicotinic acid Property
- Melting point:
- 200 °C (dec.)(lit.)
- Boiling point:
- 396.6±22.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.03±0.10(Predicted)
- form
- Powder
- color
- White to Almost white
- InChI
- InChI=1S/C6H4FNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)
- InChIKey
- JMPFWDWYGOWUFP-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=CC(C(O)=O)=C1
- CAS DataBase Reference
- 402-65-3(CAS DataBase Reference)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 593885
- Product name
- 2-Fluoro-4-pyridinecarboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $82.3
- Updated
- 2023/01/07
TCI Chemical
- Product number
- F0693
- Product name
- 2-Fluoroisonicotinic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0693
- Product name
- 2-Fluoroisonicotinic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $63
- Updated
- 2025/07/31
TRC
- Product number
- F596268
- Product name
- 2-Fluoropyridine-4-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- F596268
- Product name
- 2-Fluoropyridine-4-carboxylicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
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2-Fluoroisonicotinic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder, solubility in water, ethanol, and methanol, as well as high solubility in organic solvents.
Uses
2-Fluoroisonicotinic acid is a catalyst in organic reactions and serves as a starting material for the synthesis of fluorinated compounds. Furthermore, it plays a role in the synthesis of dyes, pigments, and various other organic compounds.
Synthesis
461-87-0
402-65-3
General procedure for the preparation of 2-fluoroisonicotinic acid: 1. 5.00 g (45 mmol) of 2-fluoro-4-methylpyridine and 1.00 g (17 mmol) of KOH were added to a reaction flask followed by 50 ml of pyridine as solvent. 2. The reaction mixture was heated to reflux. 3. 20.00 g (127 mmol) of potassium permanganate was added in batches over 30 minutes at reflux temperature. 4. After addition, the reaction mixture was continued to be heated at reflux for 1.5 hours. 5. Upon completion of the reaction, the mixture was cooled to room temperature in an ice bath. 6. 100 ml of water was added to the cooled mixture and the pH was subsequently adjusted to 1 with concentrated hydrochloric acid. 7. 100 ml of ethyl acetate was added and the insoluble material was removed by filtration. 8. The aqueous phase was extracted twice with ethyl acetate, 100 ml each time. 9. Combine all ethyl acetate phases and dry with magnesium sulfate. 10. The dried organic phase was concentrated under pressure to give 2.70 g of 2-fluoroisonicotinic acid. Yield: 42%.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 8, p. 2745 - 2766
[2] Patent: US6358978, 2002, B1
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675
[4] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 4152
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View Lastest Price from 2-Fluoroisonicotinic acid manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 2-Fluoroisonicotinic acid 402-65-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 2-Fluoroisonicotinic acid 402-65-3
- Price
- US $0.00/G
- Min. Order
- 100G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-03
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2-Fluoroisonicotinic acid 402-65-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
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