ICRF-186

Product Name: ICRF-186
CAS No.: 24613-06-7
Chemical Name: ICRF-186
Synonyms: ICRF-186;NSC-169779;NSC 169779;(R)-Razoxane;Razoxane, (R)-;R- Dexrazoxane;Dexrazoxane Impurity 8;Dexrazoxane Impurity 9;Carvedilol Impurity 36;(R)-Razoxane (Levrazoxane)
CBNumber: CB82169369
Molecular Formula: C11H16N4O4
Formula Weight: 268.27
MOL File: 24613-06-7.mol

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ICRF-186 Property

Boiling point:: 531.5±50.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
pka: 11.00±0.20(Predicted)
InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m1/s1
InChIKey: BMKDZUISNHGIBY-SSDOTTSWSA-N
SMILES: [C@@H](N1CC(=O)NC(=O)C1)(C)CN1CC(=O)NC(=O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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ICRF-186 Chemical Properties,Usage,Production

Uses

(R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases[1].

References

[1] Hasinoff BB, et al. Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte. Xenobiotica. 1994 Oct;24(10):977-87. DOI:10.3109/00498259409043295

ICRF-186 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICRF-186 Suppliers

China 19 United States 2 Global 21

Chengdu Bochen Chuangke Biomedical Technology Co., Ltd.

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SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

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QUALITY CONTROL SOLUTIONS LTD.

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TargetMol Chemicals Inc.

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Moxin Chemicals

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View Lastest Price from ICRF-186 manufacturers

Moxin Chemicals

Product: Dexrazoxane Impurity 24613-06-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 10000000
Release date: 2024-12-10

24613-06-7, ICRF-186Related Search:

Glycine, N-(2-amino-2-oxoethyl)-N-[2-(3,5-dioxo-1-piperazinyl)propyl]- Glycine, N-(2-amino-2-oxoethyl)-N-[(2R)-2-(3,5-dioxo-1-piperazinyl)propyl]- (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid 2,2',2'',2'''-[[(1S)-1-Methyl-1,2-ethanediyl]dinitrilo]tetrakisacetamide N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine ICRF 198 N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine Dexrazoxane

4,4'-[(R)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione)

ICRF-186

R- Dexrazoxane

(R)-Razoxane (Levrazoxane)

2,6-Piperazinedione, 4,4'-[(1R)-1-methyl-1,2-ethanediyl]bis- (9CI)

(R)-4,4'-(propane-1,2-diyl)bis(piperazine-2,6-dione)

Dexrazoxane Impurity 9

Dexrazoxane Impurity 8

NSC 169779

NSC-169779

Razoxane, (R)-

Carvedilol Impurity 36

(R)-Razoxane

24613-06-7