ChemicalBook > CAS DataBase List > 4-(Pyridin-3-yl)pyrimidin-2-amine

4-(Pyridin-3-yl)pyrimidin-2-amine

Product Name
4-(Pyridin-3-yl)pyrimidin-2-amine
CAS No.
66521-66-2
Chemical Name
4-(Pyridin-3-yl)pyrimidin-2-amine
Synonyms
4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;BUTTPARK 41\09-83;)-2-pyrimidine amine;4-(3-Pyridyl)-2-pyrimidinamine;Nilotinib 3-Pyridinyl Impurity;4-(3-Pyridyl)-2-pyrimidineamine;2-Amino-4-(3-pyridyl)pyrimidine;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-Pyridinyl)-2-aminopyrimidine;2-PyriMidinaMine,4-(3-pyridinyl)-
CBNumber
CB8228031
Molecular Formula
C9H8N4
Formula Weight
172.19
MOL File
66521-66-2.mol
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4-(Pyridin-3-yl)pyrimidin-2-amine Property

Melting point:
189-191 °C
Boiling point:
439.9±37.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.76±0.10(Predicted)
color 
Off-White to Pale Yellow
InChI
InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)
InChIKey
LQHQKYWYKPLKCH-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC(C2=CC=CN=C2)=N1
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Safety

Hazard Codes 
T
Risk Statements 
25-20/21/22
Safety Statements 
45-36/37
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2666
Product name
4-(Pyridin-3-yl)pyrimidin-2-amine
Packaging
1G
Price
$87
Updated
2024/03/01
TCI Chemical
Product number
P2666
Product name
4-(Pyridin-3-yl)pyrimidin-2-amine
Packaging
5G
Price
$303
Updated
2024/03/01
TRC
Product number
P991700
Product name
4-(3-Pyridinyl)-2-pyrimidinamine
Packaging
500mg
Price
$525
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-1J
Product name
4-(Pyridin-3-yl)pyrimidin-2-amine
Packaging
25g
Price
$592
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
61465
Product name
4-(3-Pyridinyl)-2-pyrimidinamine
Packaging
100mg
Price
$620
Updated
2021/12/16
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4-(Pyridin-3-yl)pyrimidin-2-amine Chemical Properties,Usage,Production

Chemical Properties

White to off-white or brown solid.

Uses

4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.

Synthesis

3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).

4-(Pyridin-3-yl)pyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Sodium N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

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4-(Pyridin-3-yl)pyrimidin-2-amine Suppliers

Canada 1 China 142 India 7 Japan 1 United Kingdom 4 United States 18 Global 173
Key Organics Limited/Bionet Research
Tel
--
Fax
--
Email
enquiries@keyorganics.ltd.uk
Country
United Kingdom
ProdList
6663
Advantage
50
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Butt Park Ltd.
Tel
--
Fax
--
Email
113707.50@compuserve.com
Country
United Kingdom
ProdList
6078
Advantage
30
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View Lastest Price from 4-(Pyridin-3-yl)pyrimidin-2-amine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-(Pyridin-3-yl)pyrimidin-2-amine 66521-66-2
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-11-20
Dideu Industries Group Limited
Product
4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-10

66521-66-2, 4-(Pyridin-3-yl)pyrimidin-2-amineRelated Search:

2-Aminopyrimidine 3-Aminopyridine Molasses 2-Aminopyridine 4-Dimethylaminopyridine Nilotinib N-Oxide Nilotinib Impurity 4 Benzenamine, 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)- Nilotinib 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine 3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide 3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-Benzenamine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine Imatinib N-Desmethyl Imatinib 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE 4-METHYL-6-PYRIDIN-3-YLPYRIMIDIN-2-AMINE

  • BUTTPARK 41\09-83
  • 4-(3-PYRIDINYL)-2-PYRIMIDINAMINE
  • 4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE
  • 4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE
  • 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE
  • 4-(3-Pyridyl)-2-pyrimidinamine
  • 4-(3-Pyridinyl)-2-aminopyrimidine
  • 4-(3-Pyridyl)-2-pyrimidineamine
  • 4-(3-Pyridinyl)-2-pyrimidine amine ,97%
  • 2-amino-4-(3-pyridinyl)-pyrimidine
  • 4-Pyridin-3-yl-pyriMidin-2-ylaMine
  • 2-PyriMidinaMine,4-(3-pyridinyl)-
  • 2-Amino-4-(3-pyridyl)pyrimidine
  • 4-(3-piridinyl)-2-pirimidine amine
  • 4-(3-Pyridinyl)-2-pyrimidine amine, 97%, reagent grade
  • )-2-pyrimidine amine
  • Nilotinib 3-Pyridinyl Impurity
  • 4-(3-Pyridinyl)-2-aminopyrimidine ISO 9001：2015 REACH
  • 4-(3-Pyridinyl)-2-aminopyrimidineQ: What is 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the CAS Number of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the storage condition of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What are the applications of 4-(3-Pyridinyl)-2-aminopyrimidine
  • 66521-66-2
  • C9H8N4
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals