(6-CHLOROPYRAZIN-2-YL)ACETIC ACID
Application- Product Name
- (6-CHLOROPYRAZIN-2-YL)ACETIC ACID
- CAS No.
- 930798-25-7
- Chemical Name
- (6-CHLOROPYRAZIN-2-YL)ACETIC ACID
- Synonyms
- 6-chloro-2-Pyrazineacetic acid;2-Pyrazineacetic acid, 6-chloro-;(6-CHLOROPYRAZIN-2-YL)ACETIC ACID;2-(6-chloropyrazin-2-yl)acetic acid;(6-CHLOROPYRAZIN-2-YL)ACETIC ACID ISO 9001：2015 REACH
- CBNumber
- CB82452425
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 930798-25-7.mol
(6-CHLOROPYRAZIN-2-YL)ACETIC ACID Property
- Boiling point:
- 317.2±37.0 °C(Predicted)
- Density
- 1.497±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.50±0.10(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C6H5ClN2O2/c7-5-3-8-2-4(9-5)1-6(10)11/h2-3H,1H2,(H,10,11)
- InChIKey
- GKCGKFUOTLQOGO-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=NC(Cl)=CN=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381233
- Product name
- (6-Chloropyrazin-2-yl)aceticacid
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FC144173
- Product name
- 2-(6-Chloropyrazin-2-yl)acetic acid
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC144173
- Product name
- 2-(6-Chloropyrazin-2-yl)acetic acid
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 072997
- Product name
- (6-Chloropyrazin-2-yl)acetic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FC144173
- Product name
- 2-(6-Chloropyrazin-2-yl)acetic acid
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
(6-CHLOROPYRAZIN-2-YL)ACETIC ACID Chemical Properties,Usage,Production
Application
(6-Chloropyrazin-2-yl)acetic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical production processes.
Synthesis
930798-26-8
930798-25-7
Step 2: To a 20L three-necked round-bottomed flask was added deionized water (9L) and sodium hydroxide (900g, 22.50 mol, 3.07 eq.) in batches and stirred well. Under stirring, 1,3-diethyl 2-(6-chloropyrazin-2-yl)malonate (2 kg, 1.00 eq., crude) was added slowly and dropwise while the reaction temperature was controlled to be lower than 10°C. The reaction was carried out at a temperature below 10°C. The reaction was carried out at a temperature below 10°C. After completion of the reaction, the mixture was stirred at room temperature overnight and then cooled to 0°C. The pH of the reaction solution was adjusted to 9-10 with 37% hydrochloric acid and subsequently extracted with ethyl acetate (3 x 2 L). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was washed with petroleum ether (1 x 1.5 L) and methyl tert-butyl ether (1 x 1.5 L), dried again with anhydrous sodium sulfate and concentrated under reduced pressure to give 463.6 g (37% yield) of 2-(6-chloropyrazin-2-yl)acetic acid as a yellow solid.
References
[1] Patent: WO2007/35153, 2007, A1. Location in patent: Page/Page column 4-5
[2] Patent: WO2007/35154, 2007, A1. Location in patent: Page/Page column 28-29
[3] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0325; 0322
(6-CHLOROPYRAZIN-2-YL)ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (6-CHLOROPYRAZIN-2-YL)ACETIC ACID manufacturers
- Product
- (6-CHLOROPYRAZIN-2-YL)ACETIC ACID 930798-25-7
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 20TONS
- Release date
- 2025-11-04
- Product
- (6-CHLOROPYRAZIN-2-YL)ACETIC ACID 930798-25-7
- Price
- US $0.10-0.30/kg
- Min. Order
- 1kg
- Purity
- 97%
- Supply Ability
- 20 tons
- Release date
- 2024-01-20