ChemicalBook > CAS DataBase List > D[LEU4,LYS8]-VP
D[LEU4,LYS8]-VP
- Product Name
- D[LEU4,LYS8]-VP
- CAS No.
- 42061-33-6
- Chemical Name
- D[LEU4,LYS8]-VP
- Synonyms
- D[LEU4,LYS8]-VP;(Deamino-Cys1,Leu?,Lys?)-Vasopressin;MPR-TYR-PHE-LEU-ASN-CYS-PRO-LYS-GLY-NH2;3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2;(Deamino-Cys?,Leu?,Lys?)-Vasopressin trifluoroacetate salt;Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-leucyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysyl-, cyclic (1→5)-disulfide;(Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
- CBNumber
- CB82456357
- Molecular Formula
- C47H67N11O11S2
- Formula Weight
- 1026.24
- MOL File
- 42061-33-6.mol
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D[LEU4,LYS8]-VP Property
- Boiling point:
- 1493.5±65.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 9.90±0.15(Predicted)
- form
- Powder
- Water Solubility
- Soluble to 2 mg/ml in water
- Sequence
- {Mpa}-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly (Disulfide bridge:Mpa1-Cys6)
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N-Bromosuccinimide Price
Tocris
- Product number
- 3127
- Product name
- d[leu4,Lys8]-VP
- Packaging
- 1
- Price
- $335
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD109910
- Product name
- (Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
- Packaging
- 250ug
- Price
- $105
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD109910
- Product name
- (Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
- Packaging
- 500ug
- Price
- $180
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD109910
- Product name
- (Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond)
- Packaging
- 1mg
- Price
- $315
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5383
- Product name
- d[Leu4,Lys8]-VP
- Packaging
- 1mg
- Price
- $497
- Updated
- 2021/12/16
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D[LEU4,LYS8]-VP Chemical Properties,Usage,Production
Uses
D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].
References
[1] Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. DOI:10.1210/en.2006-1633
[2] Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47. DOI:10.1021/jm060928n
D[LEU4,LYS8]-VP Preparation Products And Raw materials
Raw materials
Preparation Products
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D[LEU4,LYS8]-VP Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
42061-33-6, D[LEU4,LYS8]-VPRelated Search:
3-MERCAPTOPROPIONYL-BETA-3-PYRIDYL-D-ALA-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, (DISULFIDE BOND)
3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
Desmopressin
(DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN
(DEAMINO-CYS1,D-ORN8)-VASOPRESSIN
(DEAMINO-CYS1,VAL4,D-ARG8)-VASOPRESSIN
D[LEU4,LYS8]-VP