2-PYRIDINAMINE, 4-CHLORO-5-IODO-

Product Name: 2-PYRIDINAMINE, 4-CHLORO-5-IODO-
CAS No.: 670253-37-9
Chemical Name: 2-PYRIDINAMINE, 4-CHLORO-5-IODO-
Synonyms: 4-Chloro-5-iodo-2-pyridinamine;2-Amino-4-chloro-5-iodopyridine;2-PYRIDINAMINE, 4-CHLORO-5-IODO-;4-Chloro-5-iodo-pyridin-2-ylaMine;2-Amino-4-chloro-5-iodopyridine 98%
CBNumber: CB82467418
Molecular Formula: C5H4ClIN2
Formula Weight: 254.46
MOL File: 670253-37-9.mol

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2-PYRIDINAMINE, 4-CHLORO-5-IODO- Property

Boiling point:: 326.8±42.0 °C(Predicted)
Density: 2.139±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.87±0.24(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C5H4ClIN2/c6-3-1-5(8)9-2-4(3)7/h1-2H,(H2,8,9)
InChIKey: MBEBQNFNTISDFJ-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(I)C(Cl)=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 3H30-M-08
Product name: 2-Amino-4-chloro-5-iodopyridine
Packaging: 1g
Price: $92
Updated: 2021/12/16

Matrix Scientific

Product number: 071085
Product name: 4-Chloro-5-iodopyridin-2-amine
Purity: 97%
Packaging: 1g
Price: $109
Updated: 2021/12/16

Matrix Scientific

Product number: 071085
Product name: 4-Chloro-5-iodopyridin-2-amine
Purity: 97%
Packaging: 5g
Price: $180
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-M-08
Product name: 2-Amino-4-chloro-5-iodopyridine
Packaging: 5G
Price: $272
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-M-08
Product name: 2-Amino-4-chloro-5-iodopyridine
Packaging: 10g
Price: $453
Updated: 2021/12/16

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2-PYRIDINAMINE, 4-CHLORO-5-IODO- Chemical Properties,Usage,Production

Synthesis

19798-80-2

670253-37-9

General procedure for the synthesis of 4-chloro-5-iodo-2-aminopyridine from 2-amino-4-chloropyridine: 2-amino-4-chloropyridine (1.00 g, 7.78 mmol) was dissolved in N,N-dimethylformamide (DMF, 40 mL), and the reaction flask was covered with aluminum foil to avoid light. N-iodosuccinimide (NIS, 970 mg, 4.28 mmol) was subsequently added. The reaction mixture was stirred at room temperature for 19 hours, then NIS (970 mg, 4.28 mmol) was added again and stirring was continued for 24 hours. Upon completion of the reaction, the reaction was quenched by the addition of deionized water (200 mL) and extracted with ethyl acetate (EtOAc, 2 x 250 mL). The organic phases were combined, washed sequentially with deionized water (2 × 200 mL) and saturated saline (200 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure. The crude product was recrystallized with ethanol (EtOH), and the mother liquor was recrystallized again to obtain orange needle-like crystals of the target product 4-chloro-5-iodo-2-aminopyridine (1.45 g, 73% yield).

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 84, p. 404 - 416
[2] Patent: WO2015/100609, 2015, A1. Location in patent: Page/Page column 47
[3] Patent: US2012/245144, 2012, A1. Location in patent: Page/Page column 125-126
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 985 - 1002
[5] Patent: WO2013/91011, 2013, A1. Location in patent: Page/Page column 64

2-PYRIDINAMINE, 4-CHLORO-5-IODO- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PYRIDINAMINE, 4-CHLORO-5-IODO- Suppliers

China 87 India 1 United Kingdom 2 United States 7 Global 97

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View Lastest Price from 2-PYRIDINAMINE, 4-CHLORO-5-IODO- manufacturers

Career Henan Chemical Co

Product: 2-PYRIDINAMINE, 4-CHLORO-5-IODO- 670253-37-9
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

670253-37-9, 2-PYRIDINAMINE, 4-CHLORO-5-IODO-Related Search:

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2-Amino-4-chloro-5-iodopyridine 98%

670253-37-9