CAY10526

ChemicalBook > CAS DataBase List > CAY10526

Product Name: CAY10526
CAS No.: 938069-71-7
Chemical Name: CAY10526
Synonyms: CAY10526;CAY10526 Exclusive;2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-;3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one;WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase
CBNumber: CB82590422
Molecular Formula: C12H7BrO3S
Formula Weight: 311.15
MOL File: 938069-71-7.mol

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CAY10526 Property

Boiling point:: 561.7±50.0 °C(Predicted)
Density: 1.889±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid
pka: 8.90±0.60(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010088
Product name: CAY10526
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10010088
Product name: CAY10526
Purity: ≥98%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 10010088
Product name: CAY10526
Purity: ≥98%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

AK Scientific

Product number: 1400AH
Product name: 4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one
Packaging: 1mg
Price: $160
Updated: 2021/12/16

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CAY10526 Chemical Properties,Usage,Production

Description

Prostaglandin E₂ (PGE₂) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE₂ during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE₂ production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE₂ production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC₅₀ value of 1.8 μM without any effect on COX-2 expression.

CAY10526 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10526 Suppliers

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938069-71-7, CAY10526Related Search:

CAY10526

CAY10526 Exclusive

3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one

2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-

WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase

4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one

938069-71-7