6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine

Product Name: 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
CAS No.: 1042224-63-4
Chemical Name: 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
Synonyms: 6-imidazo[1;IRAK inhibitor;IRAK inhibitor 1;Cyclopamine inhibitor 1;2-a]pyridin-3-yl-N-4-piperidinyl-;6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine;2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-;6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine;IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK
CBNumber: CB82604194
Molecular Formula: C17H19N5
Formula Weight: 293.37
MOL File: 1042224-63-4.mol

More

Less

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Property

Density: 1.32
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO
form: Powder
pka: 9.94±0.10(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: A3500
Product name: IRAKinhibitor1
Packaging: 5mg
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-0603
Product name: IRAKinhibitor1
Purity: >99.0%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

ApexBio Technology

Product number: A3500
Product name: IRAKinhibitor1
Packaging: 10mg
Price: $307
Updated: 2021/12/16

ApexBio Technology

Product number: A3500
Product name: IRAKinhibitor1
Packaging: 50mg
Price: $378
Updated: 2021/12/16

ChemScene

Product number: CS-0603
Product name: IRAKinhibitor1
Purity: >99.0%
Packaging: 10mg
Price: $396
Updated: 2021/12/16

More

Less

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Chemical Properties,Usage,Production

Biological Activity

the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4).

in vitro

the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1].

target

IRAK-4

IC 50

35 nm for irak-4

References

[1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5.

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Suppliers

China 58 United States 10 Global 68

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7268
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

1042224-63-4, 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamineRelated Search:

libaotao Urease inhibitor Veliparib NS-398 IRAK-1/4 INHIBITOR I N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide 4-[[[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide 4-[6-[[(Furan-2-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl]phenol

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine

Cyclopamine inhibitor 1

IRAK inhibitor 1

2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-

2-a]pyridin-3-yl-N-4-piperidinyl-

6-imidazo[1

IRAK inhibitor

IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK

6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine

1042224-63-4