AM-211

Product Name: AM-211
CAS No.: 1175526-27-8
Chemical Name: AM-211
Synonyms: AM-211;AM211 free acid;AM211, 10 mM in DMSO;OPXIRFWNLBDKQB-UHFFFAOYSA-N;AM211 (Synonyms: AM211 free acid);inhibit,AM211,Inhibitor,Prostaglandin Receptor,AM 211,AM-211;2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid;2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid;[1,1'-Biphenyl]-3-acetic acid, 2'-[[ethyl[[(phenylmethyl)amino]carbonyl]amino]methyl]-6-methoxy-4'-(trifluoromethyl)-
CBNumber: CB82627313
Molecular Formula: C27H27F3N2O4
Formula Weight: 500.51
MOL File: 1175526-27-8.mol

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AM-211 Property

Boiling point:: 656.4±55.0 °C(Predicted)
Density: 1.264±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 125 mg/mL (249.75 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 4.38±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0003178
Product name: AM211
Purity: 99.94%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0003178
Product name: AM211
Purity: 99.94%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013768
Product name: AM-211
Purity: 95.00%
Packaging: 5MG
Price: $505.23
Updated: 2021/12/16

ChemScene

Product number: CS-0003178
Product name: AM211
Purity: 99.94%
Packaging: 50mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0003178
Product name: AM211
Purity: 99.94%
Packaging: 100mg
Price: $990
Updated: 2021/12/16

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AM-211 Chemical Properties,Usage,Production

Uses

AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

in vivo

AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED₅₀ of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis^[1].

References

[1] Bain G, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. DOI:10.1124/jpet.111.180430

AM-211 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM-211 Suppliers

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1175526-27-8, AM-211Related Search:

AM-211

OPXIRFWNLBDKQB-UHFFFAOYSA-N

AM211 (Synonyms: AM211 free acid)

AM211 free acid

[1,1'-Biphenyl]-3-acetic acid, 2'-[[ethyl[[(phenylmethyl)amino]carbonyl]amino]methyl]-6-methoxy-4'-(trifluoromethyl)-

inhibit,AM211,Inhibitor,Prostaglandin Receptor,AM 211,AM-211

2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid

AM211, 10 mM in DMSO

2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid

1175526-27-8