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AM-211

Product Name
AM-211
CAS No.
1175526-27-8
Chemical Name
AM-211
Synonyms
AM-211;AM211 free acid;AM211, 10 mM in DMSO;OPXIRFWNLBDKQB-UHFFFAOYSA-N;AM211 (Synonyms: AM211 free acid);inhibit,AM211,Inhibitor,Prostaglandin Receptor,AM 211,AM-211;2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid;2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid;[1,1'-Biphenyl]-3-acetic acid, 2'-[[ethyl[[(phenylmethyl)amino]carbonyl]amino]methyl]-6-methoxy-4'-(trifluoromethyl)-
CBNumber
CB82627313
Molecular Formula
C27H27F3N2O4
Formula Weight
500.51
MOL File
1175526-27-8.mol
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AM-211 Property

Boiling point:
656.4±55.0 °C(Predicted)
Density 
1.264±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 125 mg/mL (249.75 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
pka
4.38±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0003178
Product name
AM211
Purity
99.94%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0003178
Product name
AM211
Purity
99.94%
Packaging
10mg
Price
$150
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013768
Product name
AM-211
Purity
95.00%
Packaging
5MG
Price
$505.23
Updated
2021/12/16
ChemScene
Product number
CS-0003178
Product name
AM211
Purity
99.94%
Packaging
50mg
Price
$590
Updated
2021/12/16
ChemScene
Product number
CS-0003178
Product name
AM211
Purity
99.94%
Packaging
100mg
Price
$990
Updated
2021/12/16
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AM-211 Chemical Properties,Usage,Production

Uses

AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

in vivo

AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED50 of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis[1].

References

[1] Bain G, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. DOI:10.1124/jpet.111.180430

AM-211 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM-211 Suppliers

China 31 United States 5 Global 36
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
ProdList
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
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liming@bio-fount.com
Country
China
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9729
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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Shanghai Dongyang Biotechnology Co., Ltd.
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0512-0512-13601744364 13601744364
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chemsharker@126.com
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China
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1175526-27-8, AM-211Related Search:


  • AM-211
  • OPXIRFWNLBDKQB-UHFFFAOYSA-N
  • AM211 (Synonyms: AM211 free acid)
  • AM211 free acid
  • [1,1'-Biphenyl]-3-acetic acid, 2'-[[ethyl[[(phenylmethyl)amino]carbonyl]amino]methyl]-6-methoxy-4'-(trifluoromethyl)-
  • inhibit,AM211,Inhibitor,Prostaglandin Receptor,AM 211,AM-211
  • 2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid
  • AM211, 10 mM in DMSO
  • 2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid
  • 1175526-27-8