AM-211
- Product Name
- AM-211
- CAS No.
- 1175526-27-8
- Chemical Name
- AM-211
- Synonyms
- AM-211;AM211 free acid;AM211, 10 mM in DMSO;OPXIRFWNLBDKQB-UHFFFAOYSA-N;AM211 (Synonyms: AM211 free acid);inhibit,AM211,Inhibitor,Prostaglandin Receptor,AM 211,AM-211;2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid;2-(2'-((3-Benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid;[1,1'-Biphenyl]-3-acetic acid, 2'-[[ethyl[[(phenylmethyl)amino]carbonyl]amino]methyl]-6-methoxy-4'-(trifluoromethyl)-
- CBNumber
- CB82627313
- Molecular Formula
- C27H27F3N2O4
- Formula Weight
- 500.51
- MOL File
- 1175526-27-8.mol
AM-211 Property
- Boiling point:
- 656.4±55.0 °C(Predicted)
- Density
- 1.264±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 125 mg/mL (249.75 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 4.38±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0003178
- Product name
- AM211
- Purity
- 99.94%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0003178
- Product name
- AM211
- Purity
- 99.94%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- API0013768
- Product name
- AM-211
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.23
- Updated
- 2021/12/16
- Product number
- CS-0003178
- Product name
- AM211
- Purity
- 99.94%
- Packaging
- 50mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- CS-0003178
- Product name
- AM211
- Purity
- 99.94%
- Packaging
- 100mg
- Price
- $990
- Updated
- 2021/12/16
AM-211 Chemical Properties,Usage,Production
Uses
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
in vivo
AM211 (1, 10, and 30 mg/kg, p.o.) dose-dependently decreases in the number of DK-PGD2-induced peripheral blood leukocytes, with a calculated ED50 of 0.85 mg/kg. AM211 (30 mg/kg) also decreases antigen-induced pulmonary inflammation in guinea pigs. AM211 (10 mg/kg, p.o.) causes significant decrease in ovalbumin (OVA)-induced sneezing in a mouse model of allergic rhinitis[1].
References
[1] Bain G, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. DOI:10.1124/jpet.111.180430
AM-211 Preparation Products And Raw materials
Raw materials
Preparation Products
AM-211 Suppliers
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