2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
- Product Name
- 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
- CAS No.
- 1280210-79-8
- Chemical Name
- 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate;Omarigliptin Impurity 9;tert-butyl pyrrolo[3,4-c]pyrazole-5(2H,4H,6H)-carboxylate;tert-butyl 4,6-dihydro-2H-pyrrolo[3,4-c]pyrazole-5-carboxylate;5-tert-Butoxycarbonyl-1,4,5,6-tetrahydropyrrolo-[3,4-c]-pyra...;tert-butyl 4,6-dihy dropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate;2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester;2,6-Dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid 1,1-dimethylethyl ester;Pyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid, 2,6-dihydro-, 1,1-dimethylethyl ester
- CBNumber
- CB82629665
- Molecular Formula
- C10H15N3O2
- Formula Weight
- 209.24
- MOL File
- 1280210-79-8.mol
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester Property
- Boiling point:
- 366.0±42.0 °C(Predicted)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.52±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C10H15N3O2/c1-10(2,3)15-9(14)13-5-7-4-11-12-8(7)6-13/h4H,5-6H2,1-3H3,(H,11,12)
- InChIKey
- IBUNCTVDGYIKAP-UHFFFAOYSA-N
- SMILES
- N1C=C2CN(C(OC(C)(C)C)=O)CC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5392AA
- Product name
- tert-Butyl4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Packaging
- 1g
- Price
- $123
- Updated
- 2021/12/16
- Product number
- CHM0394142
- Product name
- TERT-BUTYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(2H)-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501
- Updated
- 2021/12/16
- Product number
- CM189052
- Product name
- 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylicacidtert-butylester
- Purity
- 95+%
- Packaging
- 10g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- ACI-02625
- Product name
- 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylicacidtert-butylester
- Purity
- 95%+
- Packaging
- 10g
- Price
- $819.25
- Updated
- 2021/12/16
- Product number
- ACI-02625
- Product name
- 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylicacidtert-butylester
- Purity
- 95%+
- Packaging
- 10g
- Price
- $819.25
- Updated
- 2021/12/16
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
157327-42-9
1280210-79-8
The reaction of tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (1 g, 4.16 mmol, 1.00 eq.) with hydrazine hydrate (340 mg, 6.79 mmol, 1.63 eq.) in ethanol (10 mL) was stirred for 5 hours at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and the resulting residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether as eluent (gradient elution from 1:5 to 1:2). The final product was 250 mg of tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate in 29% yield as a yellow solid. The product was analyzed by LC/MS (Method C, ESI): retention time RT = 1.30 min, mass spectrum m/z ~ 210.0 [M + H]+.
References
[1] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 97; 98
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 19, p. 5361 - 5366
[3] Patent: EP3144310, 2017, A1
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester manufacturers
- Product
- 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 1280210-79-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-02