2-(2-cyano-4-Methoxyphenyl)acetic acid
- Product Name
- 2-(2-cyano-4-Methoxyphenyl)acetic acid
- CAS No.
- 52786-67-1
- Chemical Name
- 2-(2-cyano-4-Methoxyphenyl)acetic acid
- Synonyms
- 2-Cyano-4-Methoxyphenylacetic acid;Benzeneacetic acid, 2-cyano-4-methoxy-;2-(2-cyano-4-Methoxyphenyl)acetic acid
- CBNumber
- CB82671497
- Molecular Formula
- C10H9NO3
- Formula Weight
- 191.18
- MOL File
- 52786-67-1.mol
2-(2-cyano-4-Methoxyphenyl)acetic acid Property
- storage temp.
- Sealed in dry,Room Temperature
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR947312
- Product name
- 2-(2-Cyano-4-methoxyphenyl)aceticacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 1444AQ
- Product name
- 2-(2-CYANO-4-METHOXYPHENYL)ACETICACID
- Packaging
- 1g
- Price
- $414.8
- Updated
- 2021/12/16
- Product number
- OR947312
- Product name
- 2-(2-Cyano-4-methoxyphenyl)aceticacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $769
- Updated
- 2021/12/16
- Product number
- MB-20138
- Product name
- 2-(2-cyano-4-methoxyphenyl)aceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CM125536
- Product name
- 2-(2-cyano-4-methoxyphenyl)aceticacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $635
- Updated
- 2021/12/16
2-(2-cyano-4-Methoxyphenyl)acetic acid Chemical Properties,Usage,Production
Synthesis
1261620-25-0
52786-67-1
The general procedure for the synthesis of 2-(2-cyano-4-methoxyphenyl)acetic acid from the compound (CAS: 1261620-25-0) was as follows: methyl (2-cyano-4-methoxyphenyl)acetate (120 mg, 0.585 mmol) was dissolved in a solvent mixture of 10 mL of tetrahydrofuran (THF) and 2 mL of water, followed by addition of lithium hydroxide monohydrate ( LiOH-H2O, 101 mg, 2.34 mmol). The reaction mixture was heated and reacted at 55 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed under reduced pressure. The residue was dissolved in 30 mL of water and the pH was adjusted to 14 with 1 N aqueous sodium hydroxide (NaOH). the aqueous layer was washed with 50 mL of ethyl acetate and the organic phase was discarded. The aqueous phase was adjusted to pH 2-3 with 1 N hydrochloric acid (HCl) aqueous solution.Subsequently, the aqueous phase was extracted with 75 mL of ethyl acetate, the organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4). After filtration, the organic phase was concentrated to afford 86 mg (77% yield) of the target product 2-(2-cyano-4-methoxyphenyl)acetic acid (SM-1ah) as a yellow solid. The mass spectrum (ESI+) showed the molecular ion peak m/z 192.2 ([M+H]+).1H NMR (CDCl3) δ 3.81 (s, 3H), 3.84 (s, 2H), 7.09 (dd, 1H), 7.13 (d, 1H), 7.30 (d, 1H), 10.22 (br s, 1H).
References
[1] Patent: US2011/230461, 2011, A1. Location in patent: Page/Page column 31
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 2, p. 156 - 161
2-(2-cyano-4-Methoxyphenyl)acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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