ChemicalBook > CAS DataBase List > 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one

2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one

Product Name
2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
CAS No.
283173-80-8
Chemical Name
2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
Synonyms
5-bromo-8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one;Rucaparib int;2-bromo-8-fluoro-4;3-cd]indol-6(3H)-one;5-dihydro-1H-azepino[5;Rucaparib Intermediate 4;]trideca-1,4(13),5,7-tetraen-9-one;2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-on;2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)...;2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
CBNumber
CB82747954
Molecular Formula
C11H8BrFN2O
Formula Weight
283.1
MOL File
283173-80-8.mol
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2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one Property

Boiling point:
571.4±50.0 °C(Predicted)
Density 
1.751±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.53±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B701160
Product name
2-Bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
Packaging
500mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB98368
Product name
2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
Packaging
50mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB98368
Product name
2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
Packaging
100mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB98368
Product name
2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
Packaging
250mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB98368
Product name
2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
Packaging
500mg
Price
$200
Updated
2021/12/16
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2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one Chemical Properties,Usage,Production

Synthesis

1408282-26-7

283173-80-8

8-Fluoro-4,5-dihydro-1H-azabino[5,4,3-cd]indol-6(3H)-one (10 g, 49.0 mmol) was used as a feedstock and suspended in a 1 L reactor at room temperature with 225 mL of a dichloromethane/tetrahydrofuran solvent mixture (1:3, v/v). The resulting suspension was cooled to 5 °C with stirring, followed by dropwise addition of a tetrahydrofuran solution of pyridinium tribromide (17.22 g, 53.9 mmol, dissolved in 75 mL of tetrahydrofuran). The reaction temperature was maintained at 5 °C and stirred continuously for 2 h until the reaction was complete. After completion of the reaction, 100 mL of water was added to give a clarified orange solution. The solution was concentrated under reduced pressure until crystals began to precipitate. Next, 750 mL of saturated sodium carbonate solution was added and the mixture was stirred at room temperature for 1 hour to form a suspension. The crystals were collected by filtration, washed with 100 mL of water, and subsequently dried in a vacuum oven at 55 °C for 4 h. 11.3 g of the target product, 2-bromo-8-fluoro-4,5-dihydro-1H-azabino[5,4,3-cd]indol-6(3H)-one, was finally obtained.

References

[1] Organic Process Research and Development, 2012, vol. 16, # 12, p. 1897 - 1904
[2] ACS Chemical Neuroscience, 2018, vol. 9, # 6, p. 1259 - 1263
[3] Patent: WO2018/140377, 2018, A1. Location in patent: Paragraph 00323

2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one 283173-80-8
Price
US $22.00-88.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50kg
Release date
2025-06-25
Henan Aochuang Chemical Co.,Ltd.
Product
2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one 283173-80-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Shaanxi Dideu Medichem Co. Ltd
Product
2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one 283173-80-8
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-27

283173-80-8, 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-oneRelated Search:

1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde 8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one N-(2-Oxoethyl)phthalimide 6-Fluoro-1H-indole-4-carboxylic acid methyl ester PF-01367338

  • 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one
  • 2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
  • Rucaparib int
  • 3-cd]indol-6(3H)-one
  • 5-bromo-8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one
  • 5-bromo-8-fluoro-3,4-dihydro-2H- azepino[5,4,3-cd]indol-1(6H)-one
  • 2-bromo-8-fluoro-4
  • 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-on
  • Rucaparib Intermediate 4
  • 5-dihydro-1H-azepino[5
  • ]trideca-1,4(13),5,7-tetraen-9-one
  • 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 2-bromo-8-fluoro-1,3,4,5-tetrahydro-
  • 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)...
  • 2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
  • 5-Bromo-8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5, 4,3-cdjindol-1-one
  • 283173-80-8
  • C11H8BrFN2O