PF-5006739

Product Name: PF-5006739
CAS No.: 1293395-67-1
Chemical Name: PF-5006739
Synonyms: PF-5006739;PF 5006739;PF5006739;PF-5006739 >=98% (HPLC);4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine;4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine;2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-
CBNumber: CB83039225
Molecular Formula: C22H22FN7O
Formula Weight: 419.45
MOL File: 1293395-67-1.mol

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PF-5006739 Property

storage temp.: room temp
solubility: Soluble in DMSO
form: powder
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0246
Product name: PF-5006739
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $102
Updated: 2022/05/15

Sigma-Aldrich

Product number: PZ0246
Product name: PF-5006739
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $410
Updated: 2022/05/15

Tocris

Product number: 6346
Product name: PF5006739
Purity: ≥98%(HPLC)
Packaging: 5
Price: $68
Updated: 2021/12/16

Tocris

Product number: 6346
Product name: PF5006739
Purity: ≥98%(HPLC)
Packaging: 25
Price: $266
Updated: 2021/12/16

TRC

Product number: P294150
Product name: PF5006739
Packaging: 1mg
Price: $65
Updated: 2021/12/16

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PF-5006739 Chemical Properties,Usage,Production

Uses

PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2].

Biochem/physiol Actions

PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model.

IC 50

CK1δ: 3.9 nM (IC₅₀)

storage

Store at +4°C

References

[1] Wager TT, et al. Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65. DOI:10.1021/cn500201x
[2] Cunningham PS, et al. Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.Sci Rep. 2016 Jul 21;6:29983. DOI:10.1038/srep29983

PF-5006739 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-5006739 Suppliers

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1293395-67-1, PF-5006739Related Search:

PF-5006739

4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine

4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine

PF 5006739;PF5006739

2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-

PF-5006739 >=98% (HPLC)

1293395-67-1