PF-5006739
- Product Name
- PF-5006739
- CAS No.
- 1293395-67-1
- Chemical Name
- PF-5006739
- Synonyms
- PF-5006739;PF 5006739;PF5006739;PF-5006739 >=98% (HPLC);4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine;4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine;2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-
- CBNumber
- CB83039225
- Molecular Formula
- C22H22FN7O
- Formula Weight
- 419.45
- MOL File
- 1293395-67-1.mol
PF-5006739 Property
- storage temp.
- room temp
- solubility
- Soluble in DMSO
- form
- powder
- color
- white to beige
Safety
- RIDADR
- UN 2811 6.1 / PGIII
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PZ0246
- Product name
- PF-5006739
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $102
- Updated
- 2022/05/15
- Product number
- PZ0246
- Product name
- PF-5006739
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $410
- Updated
- 2022/05/15
- Product number
- 6346
- Product name
- PF5006739
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 6346
- Product name
- PF5006739
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $266
- Updated
- 2021/12/16
- Product number
- P294150
- Product name
- PF5006739
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
PF-5006739 Chemical Properties,Usage,Production
Uses
PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2].
Biochem/physiol Actions
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model.
IC 50
CK1δ: 3.9 nM (IC50)
storage
Store at +4°C
References
[1] Wager TT, et al. Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65. DOI:10.1021/cn500201x
[2] Cunningham PS, et al. Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.Sci Rep. 2016 Jul 21;6:29983. DOI:10.1038/srep29983
PF-5006739 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-5006739 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58