SBI-0206965

ChemicalBook > CAS DataBase List > SBI-0206965

Product Name: SBI-0206965
CAS No.: 1884220-36-3
Chemical Name: SBI-0206965
Synonyms: CS-1581;SBI-0206965;SBI-0206965（02）;SBI 0206965;SBI0206965;SBI0206965; SBI-0206965; SBI 0206965.;2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide;SBI-0206965,SBI 0206965,inhibit,Inhibitor,Unc-51 like kinase,Apoptosis,Autophagy,ULK;Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-
CBNumber: CB83039306
Molecular Formula: C21H21BrN4O5
Formula Weight: 489.32
MOL File: 1884220-36-3.mol

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SBI-0206965 Property

Melting point:: 170 - 172°C
Density: 1.434±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 30 mg/ml)
form: powder
pka: 14.80±0.46(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1540
Product name: SBI-0206965
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $159
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1540
Product name: SBI-0206965
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $639
Updated: 2023/06/20

Cayman Chemical

Product number: 18477
Product name: SBI-0206965
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18477
Product name: SBI-0206965
Purity: ≥98%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 18477
Product name: SBI-0206965
Purity: ≥98%
Packaging: 25mg
Price: $288
Updated: 2024/03/01

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SBI-0206965 Chemical Properties,Usage,Production

Description

ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. It is activated by phosphorylation by AMPK and, in turn, phosphorylates and inhibits AMPK. SBI-0206965 is an inhibitor of ULK1 (IC₅₀ = 108 nM) that is less effective against ULK2 (IC₅₀ = 711 nM). It is selective for ULK1 and ULK2 over a panel of 456 additional kinases, showing activity against a few kinases in vitro but not in cells. SBI-0206965 suppresses autophagy induced by mTOR inhibition via AZD 8055 . It also blocks ULK1-dependent cell survival following nutrient deprivation.

Uses

SBI-0206965 is an inhibitor of ULK1. It also blocks ULK1-dependent cell survival following nutrient deprivation. ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation.

Biochem/physiol Actions

Since most of the tumor cells survive on autophagy mechanism, inhibition of autophagy inducers Unc-51 (serine/threonine-protein kinase)-like autophagy activating kinase (ULK1 and ULK2) might be useful in cancer therapy.

References

1) Egan?et al. (2015), Small Molecules Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates; Mol. Cell, 59?285

SBI-0206965 Preparation Products And Raw materials

Raw materials

Preparation Products

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SBI-0206965 Suppliers

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1884220-36-3, SBI-0206965Related Search:

Sb-742457 SB9200 GSK-CXCR2 SBI-993 SB-649868 SB1317 SB 203580 SB 204741 SB1317 MANZAMINE A STF-62247 WORTMANNIN Xanthohumol SBI-0640756

SBI-0206965

SBI0206965; SBI-0206965; SBI 0206965.

CS-1581

SBI 0206965;SBI0206965

2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide

SBI-0206965（02）

Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-

SBI-0206965,SBI 0206965,inhibit,Inhibitor,Unc-51 like kinase,Apoptosis,Autophagy,ULK

1884220-36-3

C21H21BrN4O5

Inhibitors