JYL1421
- Product Name
- JYL1421
- CAS No.
- 401907-26-4
- Chemical Name
- JYL1421
- Synonyms
- JYL1421;SC 0030;JYL-1421 (SC-0030);inhibit,JYL-1421,Inhibitor,JYL 1421,SC-0030,TRP Channel,Transient receptor potential channels,JYL1421,SC0030;Methanesulfonamide, N-[4-[[[[[[4-(1,1-dimethylethyl)phenyl]methyl]amino]thioxomethyl]amino]methyl]-2-fluorophenyl]-
- CBNumber
- CB83067558
- Molecular Formula
- C20H26FN3O2S2
- Formula Weight
- 423.57
- MOL File
- 401907-26-4.mol
JYL1421 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 20458
- Product name
- JYL1421
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 20458
- Product name
- JYL1421
- Packaging
- 1mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 20458
- Product name
- JYL1421
- Packaging
- 5mg
- Price
- $333
- Updated
- 2024/03/01
- Product number
- 20458
- Product name
- JYL1421
- Packaging
- 10mg
- Price
- $427
- Updated
- 2024/03/01
- Product number
- CS-0019909
- Product name
- JYL1421
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
JYL1421 Chemical Properties,Usage,Production
Uses
JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM.
in vivo
Instillation of 50 μL capsaicin solution (10 μg/mL) into the left eye of the rat evokes 12.9±1.3 wiping movements within 3 min. Pretreating the rats with 0.4 or 1 mg/kg i.p. JYL 1421 does not influence significantly the wiping behavior, but 2-5 mg/kg dose-dependently reduces the number of wiping movements. The ID50 value is 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 Hgmm (n=6). One and 2 μg/kg capsaicin i.v. injection evokes a transient drop of blood pressure by 47.4±4.7 and 59.6±4.2 Hgmm (n=6), respectively. Both applied doses of JYL 1421 (0.4 and 1.6 mg/kg) fail to evoke hypotension. JYL 1421 dose-dependently inhibits the capsaicin-induced fall in blood pressure as shown by the need for higher capsaicin doses to elicit the reflex hypotension after JYL 1421 administration than before treatment. Capsazepine fails to induce a significant inhibition of the capsaicin-evoked hypotension up to a dose of 2 mg/kg[1].
References
[1] Jakab B, et al. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. Eur J Pharmacol. 2005 Jul 4;517(1-2):35-44. DOI:10.1016/j.ejphar.2005.05.002
JYL1421 Preparation Products And Raw materials
Raw materials
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