iKIX1
- Product Name
- iKIX1
- CAS No.
- 656222-54-7
- Chemical Name
- iKIX1
- Synonyms
- Ikixi;iKIX1;iKIX1, 10 mM in DMSO;2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide;Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide;antifungal,Inhibitor,drug-resistant,Fungal,CgGal11A,CgPdr1,infection,C. glabrata,iKIX1,inhibit,iKIX-1,iKIX 1
- CBNumber
- CB83152630
- Molecular Formula
- C10H8Cl2N4OS
- Formula Weight
- 303.17
- MOL File
- 656222-54-7.mol
iKIX1 Property
- Density
- 1.551±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- pka
- 3.76±0.10(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19839
- Product name
- iKIX1
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 19839
- Product name
- iKIX1
- Packaging
- 500μg
- Price
- $28
- Updated
- 2023/01/06
- Product number
- 19839
- Product name
- iKIX1
- Packaging
- 5mg
- Price
- $238
- Updated
- 2024/03/01
- Product number
- 19839
- Product name
- iKIX1
- Packaging
- 10mg
- Price
- $450
- Updated
- 2024/03/01
- Product number
- CS-0089717
- Product name
- iKIX1
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
iKIX1 Chemical Properties,Usage,Production
Description
iKIX1 is an inhibitor of interactions between the transcription co-activator Mediator complex and the pleitropic drug resistance (CgPdr1) transcription factor in the pathogen C. glabrata. It inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC50 = 190.2 μM). iKIX1 (10 and 30 μM) inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in C. glabrata. It increases the sensitivity of azole-resistant C. glabrata strains expressing CgPDR1 gain-of-function mutations to the antifungal compounds fluconazole and ketoconazole in a concentration-dependent manner. iKIX1 (100 mg/kg) decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant C. glabrata when administered in combination with low and high doses of fluconazole, respectively.
Uses
iKIX1 is an antifungal agent and resensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC50 and Ki values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection[1].
References
[1] Joy L Nishikawa, et al.Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25;530(7591):485-9. DOI:10.1038/nature16963
iKIX1 Preparation Products And Raw materials
Raw materials
Preparation Products
iKIX1 Suppliers
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