F-15599

Product Name: F-15599
CAS No.: 635323-95-4
Chemical Name: F-15599
Synonyms: F15;F-15;F 15;NLX101;NLX 101;F-15599;NLX-101;NLX-101 ，S3510;NLX-101 F-15599;F-15599, 10 mM in DMSO
CBNumber: CB83175541
Molecular Formula: C19H21ClF2N4O
Formula Weight: 394.85
MOL File: 635323-95-4.mol

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F-15599 Property

Melting point:: 195 °C
Boiling point:: 534.7±50.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:200.0(Max Conc. mg/mL);506.5(Max Conc. mM)
form: Solid
pka: 8.20±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6813
Product name: F-15599
Purity: 99.61%
Packaging: 1mg
Price: $1224
Updated: 2021/12/16

ChemScene

Product number: CS-6813
Product name: F-15599
Purity: 99.61%
Packaging: 5mg
Price: $2436
Updated: 2021/12/16

ChemScene

Product number: CS-6813
Product name: F-15599
Purity: 99.61%
Packaging: 10mg
Price: $4140
Updated: 2021/12/16

ChemScene

Product number: CS-6813
Product name: F-15599
Purity: 99.61%
Packaging: 20mg
Price: $7308
Updated: 2021/12/16

DC Chemicals

Product number: DC26175
Product name: NLX-101（F-15599）
Packaging: 100mg
Price: $500
Updated: 2021/12/16

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F-15599 Chemical Properties,Usage,Production

Uses

F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.

in vivo

F15599 (0.06 or 0.12 mg/kg) significantly reduces l-DOPA-induced dyskinesia (LID), without affecting motor performance of rats. Rats treated with F15599 manifest less LID and mild 5-HT syndrome with the high dose of 30 μg/μL^[1]. F15599 (0.0625, 0.125, 0.25, 0.5 and 1.0 mg/kg, i,p,) results in a significant and dose-dependent (MED?=?0.125 mg/kg) delay in the latency to attack, and a potent reduction (ID₅₀?=?0.095 mg/kg) in the amount of aggressive behaviour directed towards the intruder rat. Starting from the 0.25 mg/kg dose, F15599 induces clear signs of the so-called serotonin syndrome characterized by flat body posture, head-waving, lower lip retraction and hindlimb abduction, leading to increased behavioural inactivity scores and social disengagement^[2]. F15599 increases the discharge rate of pyramidal neurones in medial prefrontal cortex (mPFC) from 0.2 μg/kg i.v and reduces that of dorsal raphe 5-hydroxytryptaminergic neurones at doses >10-fold higher (minimal effective dose 8.2 μg/kg i.v.). F15599 increases dopamine output in mPFC (an effect dependent on the activation of postsynaptic 5-HT1A receptors) with an ED₅₀ of 30 μg/kg i.p., whereas it reduces hippocampal 5-HT release (an effect dependent exclusively on 5-HT1A autoreceptor activation) with an ED₅₀ of 240 μg/kg i.p^[3].

IC 50

5-HT_1A Receptor: 3.4 nM (Ki)

References

[1] Meadows SM, et al. Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of l-DOPA-induced dyskinesia. Exp Neurol. 2017 Jun;292:168-178. DOI:10.1016/j.expneurol.2017.03.013
[2] de Boer SF, et al. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT?A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology (Berl). 2016 Mar;233(6):937-47. DOI:10.1007/s00213-015-4173-x
[3] Lladó-Pelfort L, et al. Preferential in vivo action of F15599, a novel 5-HT(1A) receptor agonist, at postsynaptic 5-HT(1A) receptors. Br J Pharmacol. 2010 Aug;160(8):1929-40. DOI:10.1111/j.1476-5381.2010.00738.x

F-15599 Preparation Products And Raw materials

Raw materials

Preparation Products

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F-15599 Suppliers

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635323-95-4, F-15599Related Search:

F-15599

F 15

F15

F-15

NLX 101

NLX101

NLX-101

NLX-101; NLX 101; NLX101; F-15;599; F 15;599; F15;599; F15599

NLX-101 F-15599

Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[(5-methyl-2-pyrimidinyl)methyl]amino]methyl]-1-piperidinyl]-

(3-CHLORO-4-FLUOROPHENYL)-[4-FLUORO-4-[[(5-METHYLPYRIMIDIN-2-YL)METHYLAMINO]METHYL]PIPERIDIN-1-YL]METHANONE

NLX-101,inhibit,5-HT Receptor,Serotonin Receptor,NLX 101,F-15599,NLX101,F15599,F 15599,5-hydroxytryptamine Receptor,Inhibitor

F-15599, 10 mM in DMSO

NLX-101 ，S3510

635323-95-4

C19H21ClF2N4O

API